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Advancements in the co-formulation of biologic therapeutics
Biologic therapeutics are the medicines of the future and are destined to transform the approaches
by which the causes and symptoms of diseases are cured and alleviated. These approaches will
be accelerated through the ...
Insight into nanoparticle cellular uptake and intracellular targeting
(2014)
Collaborative efforts from the fields of biology, materials science, and engineering are leading to exciting progress in the development of nanomedicines. Since the targets of many therapeutic agents are localized in ...
Identification of the potential biological target of N-benzenesulfonyl-1,2,3,4-tetrahydroquinoline compounds active against gram-positive and gram-negative bacteria
(Adenine Press, 2019-06-23)
The development of new antibiotics with activity towards a broad spectrum of bacteria, including multiresistant strains, is a very important topic for global public health. As part of previous works, N-benzenesulfonyl-1, ...
Identification of potential therapeutic targets in prostate cancer through a cross-species approach
(2018-03-01)
Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development ...
Prediction of Druggable Proteins Using Machine Learning and Systems Biology: A Mini-Review
(Frontiers Media Sa, 2015-12-08)
The emergence of -omics technologies has allowed the collection of vast amounts of data on biological systems. Although, the pace of such collection has been exponential, the impact of these data remains small on many ...
Prediction of druggable proteins using machine learning and systems biology: A mini-review
(2015-01-01)
The emergence of -omics technologies has allowed the collection of vast amounts of data on biological systems. Although, the pace of such collection has been exponential, the impact of these data remains small on many ...
Prediction of drug targets in human pathogens
(Universidade Federal de Minas GeraisUFMG, 2017-02-21)
The rapid emergence of resistant bacteria makes today's antibiotics more and more ineffective, consequently increasing the need for new pharmacological targets and novel classes of antibacterial drugs. The identification ...
The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control
(2021-02-01)
Natural products are a valuable source of biologically active compounds and continue to play an important role in modern drug discovery due to their great structural diversity and unique biological properties. Brazilian ...