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Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective
(Pergamon-Elsevier Science Ltd, 2016-08)
Enhancement of α7 nicotinic receptor (nAChR) function by positive allosteric modulators (PAMs) is a promising therapeutic strategy to improve cognitive deficits. PAMs have been classified only on the basis of their macroscopic ...
Allosteric modulation of α7 nicotinic receptors by flavonoids
(SAGE Publications, 2018)
Plants have emerged as a valuable source for neuroprotective compounds like flavonoids. These polyphenolic com pounds decrease neurotoxicity and the development of neurodegeneration. Potentiation of α7 nicotinic receptor, ...
Role of the cys loop and transmembrane domain in the allosteric modulation of alpha 4 beta 2 nicotinic acetylcholine receptors
(2017)
Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel gating. Using alpha 4 beta 2 nicotinic acetylcholine receptors and the ...
Activation and modulation of the nicotinic receptor
(IOS Press, 2010-05-27)
Nicotinic acetylcholine receptors (AChRs) are the best characterized ion channels representing the Cys-loop receptor superfamily. AChRs have all the machinery to recognize the neurotransmitter ACh and other agonists such ...
Mode of cembranoid action on embryonic muscle acetylcholine receptor
(WILEY-LISS, 2008)
The mechanism of eupalmerin acetate (EUAC) actions on the embryonic muscle nicotinic acetylcholine receptor (nAChR) in BC3H-1 cells was studied by using whole-cell and single-channel patch-clamp current measurements. With ...
Positive modulation of the a9a10 nicotinic cholinergic receptor by ascorbic acid
(Wiley, 2013-01-24)
Background and Purpose:
The activation of α9α10 nicotinic cholinergic receptors (nAChRs) present at the synapse between efferent olivocochlear fibres and cochlear hair cells can prevent acoustic trauma. Hence, pharmacological ...
Role of the cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors
(American Society for Biochemistry and Molecular Biology Inc., 2017)
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel ...
Flavonoids as positive allosteric modulators of α7 nicotinic receptors
(Pergamon-Elsevier Science Ltd, 2019-12-01)
The use of positive allosteric modulators (PAM) of α7 nicotinic receptors is a promising therapy for neurodegenerative, inflammatory and cognitive disorders. Flavonoids are polyphenolic compounds showing neuroprotective, ...