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The Gating of Polycystin Signaling Complex
(Sociedad de Biología de Chile, 2004)
Structural interaction and functional regulation of polycystin-2 by filamin
(Public Library of Science, 2012-07)
Filamins are important actin cross-linking proteins implicated in scaffolding, membrane stabilization and signal transduction, through interaction with ion channels, receptors and signaling proteins. Here we report the ...
Hyperosmotic stress stimulates autophagy via polycystin-2
(Impact Journals, 2017)
Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several ...
New emerging roles of Polycystin-2 in the regulation of autophagy
(Elsevier, 2020)
Polycystin-2 (PC2) is a calcium channel that can be found in the endoplasmic reticulum, the plasmatic
membrane, and the primary cilium. The structure of PC2 is characterized by a highly ordered C-terminal
tail with an ...
Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy
(Public Library Science, 2021)
Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical ...
Polycystin-2 (TRPP2) regulation by Ca2+ is effected and diversified by actin-binding proteins
(Cell Press, 2015-05)
Calcium regulation of Ca2+-permeable ion channels is an important mechanism in the control of cell function. Polycystin-2 (PC2, TRPP2), a member of the transient receptor potential superfamily, is a nonselective cation ...
Calcium Transport and Local Pool Regulate Polycystin-2 (TRPP2) Function in Human Syncytiotrophoblast
(Cell Press, 2013-07-16)
Polycystin-2 (PC2, TRPP2) is a Ca2+ -permeable, nonselective cation channel implicated in Ca2+ transport and epithelial cell signaling. Although PC2 may contribute to Ca2+ transport in human term placenta, the regulatory ...
Lipid bilayer-atomic force microscopy combined platform records simultaneous electrical and topological changes of the TRP channel Polycystin-2 (TRPP2)
(Public Library of Science, 2018-08)
Ion channels are transmembrane proteins that mediate ion transport across biological membranes. Ion channel function is traditionally characterized by electrical parameters acquired with techniques such as patch-clamping ...