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Synergistic encapsulation of the anti-HIV agent efavirenz within mixed poloxamine/poloxamer polymeric micelles
(Elsevier Science, 2011-10)
This study investigated the synergistic performance of mixed polymeric micelles made of linear and branched poly(ethylene oxide)-poly(propylene oxide) for the more effective encapsulation of the anti-HIV drug efavirenz. ...
Inhibition of P-glycoprotein pumps by PEO–PPO amphiphiles: branched versus linear derivatives
(Future Medicine, 2010-12)
Inhibition of the activity of efflux transporters may relevantly improve the chemotherapy of cancer and infectious diseases. Aim: To explore the ability of poloxamines (Tetronic®, X-shaped structure with a central ...
Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailability
(Future Medicine, 2010-01)
Children constitute the most challenging population in anti-HIV/AIDS pharmacotherapy. Efavirenz (EFV; aqueous solubility 4 µg/ml, bioavailability 40–45%) is a first-line agent in the pediatric therapeutic cocktail. The ...
Poloxamine-based nanomaterials for drug delivery
(Frontiers In Bioscience Inc, 2010-12)
Poloxamines (Tetronic) are X-shaped amphiphilic block copolymers formed by four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks bonded to a central ethylenediamine moiety. Such a structure confers ...
Lactosylated poly(ethylene oxide)–poly(propylene oxide) block copolymers for potential active targeting: synthesis and physicochemical and self-aggregation characterization
(Springer, 2013-01-12)
Aiming to develop polymeric self-assembly nanocarriers with potential applications in active drug targeting to the liver, linear and branched poly(ethylene oxide)- poly(propylene oxide) (PEO-PPO) amphiphiles were conjugated ...
Encapsulation of the Antimicrobial and Immunomodulator Agent Nitazoxanide Within Polymeric Micelles
(American Scientific Publishers, 2014-06)
Nitazoxanide (NTZ) is a highly hydrophobic nitrothiazolyl-salicylamide that displays antimicrobial activity against a variety of parasites, anaerobic bacteria and viruses. More recently, its effectiveness in the pharmacotherapy ...
Intranasal administration of antiretroviral-loaded micelles for anatomical targeting to the brain in HIV
(Future Medicine, 2012-11-22)
We investigated the intranasal administration of poly(ethylene oxide)–poly(propylene oxide) polymeric micelles loaded with high payloads of the first-line antiretroviral drug efavirenz for targeting to the CNS. The effect ...
T908 polymeric micelles improved the uptake of Sgc8-c aptamer probe in tumor-bearing mice: A co-association study between the probe and preformed nanostructures
(MDPI, 2021-01)
Aptamers are oligonucleotides that have the characteristic of recognizing a target with high affinity and specificity. Based on our previous studies, the aptamer probe Sgc8-c-Alexa647 is a promising tool for molecular ...