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Modulação da memória emocional em camundongos: análise da interação dos sistemas histaminérgico e colinérgico na amídala
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Fisioterapia - PPGFt, 2015-02-06)
This study investigated the effects of bilateral intra-amygdala microinjections of PNU-282987, which is a nicotinic cholinergic agonist, on anxiety and emotional memory as well as the reversal of amnesia induced by an H1 ...
Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of α7 Nicotinic Acetylcholine Receptor
(Nicola Scichilone, 2021-07)
Abstract: (1) Background: The lung cholinergic pathway is important for controlling pulmonary inflammation in acute lung injury, a condition that is characterized by a sudden onset and intense inflammation. This study ...
Acute lung injury is reduced by the alpha 7nAChR agonist PNU-282987 through changes in the macrophage profile
(Federation Amer Soc Exp Biol, 2017)
Nicotinic alpha-7 acetylcholine receptor (nAChR alpha 7) is a critical regulator of cholinergic anti-inflammatory actions in several diseases, including acute respiratory distress syndrome (ARDS). Given the potential ...
Effects of VAChT reduction and α7nAChR stimulation by PNU-282987 in lung inflammation in a model of chronic allergic airway inflammation
(Elsevier, 2020-09-05)
The cholinergic anti-inflammatory pathway has been shown to regulate lung inflammation and cytokine release in acute models of inflammation, mainly via α7 nicotinic receptor (α7nAChR). We aimed to evaluate the role of ...
Expression and functional role of α7 nicotinic receptor in human cytokine-stimulated natural killer (NK) cells
(American Society for Biochemistry and Molecular Biology, 2016-06-09)
The homomeric α7 nicotinic receptor (nAChR) is one of the most abundant nAChRs in the central nervous system where it contributes to cognition, attention, and working memory. α7 nAChR is also present in lymphocytes, dendritic ...
Avaliação da expressão gênica e proteica dos receptores nicotínicos em modelo in vitro de infecção por SARS-CoV-2 com e sem superexpressão de ECA2
(Universidade Federal de São Paulo, 2023-02-27)
Introdução: O SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) é o vírus causador da COVID-19 (Coronavírus disease 2019), doença decretada pandêmica em 2020. A entrada do vírus na célula hospedeira ocorre após ...
Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in chembl
(2014)
While a plethora of ligands are known for the well studied α7 and α4β2 nicotinic acetylcholine receptor (nAChR), only very few ligands address the related α3β2 nAChR expressed in the central nervous system and at the ...
Discovery of potent positive allosteric modulators of the ?3?2 nicotinic acetylcholine receptor by a chemical space walk in chembl
(2014)
While a plethora of ligands are known for the well studied ?7 and ?4?2 nicotinic acetylcholine receptor (nAChR), only very few ligands address the related ?3?2 nAChR expressed in the central nervous system and at the ...
Discovery of potent positive allosteric modulators of the ?3?2 nicotinic acetylcholine receptor by a chemical space walk in chembl
(2009)
We work out the phase-space structure for a system of n qubits. We replace the field of real numbers that label the axes of the continuous phase space by the finite field GF(2n) and investigate the geometrical structures ...