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Dengue Non-structural Protein 5 Polymerase Complexes With Promyelocytic Leukemia Protein (PML) Isoforms III and IV to Disrupt PML-Nuclear Bodies in Infected Cells
(Frontiers Media S.A., 2019-08)
Dengue virus (DENV) threatens almost 70% of the world's population, with no therapeutic currently available. The severe, potentially lethal forms of DENV disease (dengue hemorrhagic fever/dengue shock syndrome) are associated ...
MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs
(Nature Publishing Group, 2012-06)
MAGE-A genes are a subfamily of the melanoma antigen genes (MAGEs), whose expression is restricted to tumor cells of different origin and normal tissues of the human germline. Although the specific function of individual ...
Rol antiviral intrínseco de PML en la infección con flavivirusRole of PML in the intrinsic immunity against flaviviruses
(2018-01-01)
La inmunidad intrínseca es mediada por proteínas expresadas constitutivamente por la célula y que pueden bloquear directamente la replicación viral. Mientras que la activación de la respuesta inmune innata a través de la ...
Cellular Promyelocytic Leukemia Protein Is an Important Dengue Virus Restriction Factor
(Public Library Of Science, 2015-05)
The intrinsic antiviral defense is based on cellular restriction factors that are constitutively expressed and, thus, active even before a pathogen enters the cell. The promyelocytic leukemia (PML) nuclear bodies (NBs) are ...
Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
(2011-12-01)
The Mx1 protein is encoded by an interferon- induced gene and shares domain organization, homooligomerization capacity and membrane association with the large dynamin-like GTPases. The Mx1 protein is involved in the response ...
Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
(2011-12-01)
The Mx1 protein is encoded by an interferon- induced gene and shares domain organization, homooligomerization capacity and membrane association with the large dynamin-like GTPases. The Mx1 protein is involved in the response ...
Cellular Organelles Reorganization During Zika Virus Infection of Human Cells
(Frontiers Media, 2020-07)
Zika virus (ZIKV) is an enveloped positive stranded RNA virus belonging to the genus Flavivirus in the family Flaviviridae that emerged in recent decades causing pandemic outbreaks of human infections occasionally associated ...
Caracterização funcional da proteína MxA: estudo do seu envolvimento com a mauinaria de SUMOilação
(Universidade Estadual Paulista (Unesp), 2014-09-05)
The human MxA protein is a member of the superfamily of GTPases dynamins. The so called Mx proteins are present in the majority of the vertebrate organisms investigated so far and contain two structural domains, named ...