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In vitro long-term treatment with MAPK inhibitors induces melanoma cells with resistance plasticity to inhibitors while retaining sensitivity to CD8 T cells

Madorsky Rowdo, Florencia Paula; Baron, Antonela; Von Euw, Erika María; Mordoh, Jose (Spandidos Publications, 2017-03)

The development of BRAF V600 and MEK inhibitors constitutes a breakthrough in the treatment of patients with BRAF-mutated metastatic melanoma. However, although there is an increase in overall survival, these patients ...

Epigenetic inhibitors eliminate senescent melanoma BRAFV600E cells that survive long-term BRAF inhibition

Madorsky Rowdo, Florencia Paula; Baron, Antonela; Gallagher, Stuart John; Hersey, Peter; Emran, Abdullah A. L.; Von Euw, Erika María; Barrio, Maria Marcela; Mordoh, Jose (Spandidos Publications, 2020-06)

It is estimated that ~50% of patients with melanoma harbour B-Raf (BRAF)V600 driver mutations, with the most common of these being BRAFV600E, which leads to the activation of mitogen-activated protein kinase proliferative ...

Avaliação in vitro dos efeitos citotóxicos e antimetastáticos de sais de isotiourônio, de n-fenilisotiourônio e de isotiossemicarbazidas em linhagens de melanoma

Cisilotto, Júlia (2015)

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In vitro long-term treatment with MAPK inhibitors induces melanoma cells with resistance plasticity to inhibitors while retaining sensitivity to CD8 T cells

Epigenetic inhibitors eliminate senescent melanoma BRAFV600E cells that survive long-term BRAF inhibition

Avaliação in vitro dos efeitos citotóxicos e antimetastáticos de sais de isotiourônio, de n-fenilisotiourônio e de isotiossemicarbazidas em linhagens de melanoma

New forms of induction of apoptosis in aggressive lymphoma using peptides that interrupt the RAS / RAF interaction

Assinaturas moleculares da progressão do melanoma.

BCL2l10 is overexpressed in melanoma downstream of STAT3 and promotes cisplatin and ABT-737 resistance

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In vitro long-term treatment with MAPK inhibitors induces melanoma cells with resistance plasticity to inhibitors while retaining sensitivity to CD8 T cells

Epigenetic inhibitors eliminate senescent melanoma BRAFV600E cells that survive long-term BRAF inhibition

Avaliação in vitro dos efeitos citotóxicos e antimetastáticos de sais de isotiourônio, de n-fenilisotiourônio e de isotiossemicarbazidas em linhagens de melanoma

New forms of induction of apoptosis in aggressive lymphoma using peptides that interrupt the RAS / RAF interaction

Assinaturas moleculares da progressão do melanoma.

BCL2l10 is overexpressed in melanoma downstream of STAT3 and promotes cisplatin and ABT-737 resistance