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Dynamical reorganization of the pluripotency transcription factors Oct4 and Sox2 during early differentiation of embryonic stem cells
(Nature, 2020-03)
Pluripotency maintenance requires transcription factors (TFs) that induce genes necessary to preserve the undifferentiated state and repress others involved in differentiation. Recent observations support that the heterogeneous ...
Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells? Transcription Factors
(Public Library of Science, 2015-12)
Pluripotent stem cells possess complex systems that protect them from oxidative stress and ensure genomic stability, vital for their role in development. Even though it has been reported that antioxidant activity diminishes ...
Generation of neural progenitor cells from porcine-induced pluripotent stem cells
(Wiley-Blackwell, 2020-11-23)
In this study, porcine embryonic fibroblasts (pEFs) were reprogrammed into porcine-induced pluripotent stem cells (piPSCs) using either human or mouse specific sequences for the OCT4, SOX2, c-Myc, and KLF4 transcription ...
Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo
(Cell Press, 2016-03)
Transcription factor (TF) binding to DNA is fundamental for gene regulation. However, it remains unknown how the dynamics of TF-DNA interactions change during cell-fate determination in vivo. Here, we use photo-activatable ...
Stem cells in development and the perspectives of cellular reprogramming for regeneration Células troncales en el desarrollo y las perspectivas de reprogramación celular para la regeneración
(2012)
Multicellular organisms develop from one cell: the zygote. During ontogeny, cells derived from the zygote display different cellular programs that are stabilized through epigenetic mechanisms. The programs of stem cells ...
Modulation of chromatin modifying factors' gene expression in embryonic and induced pluripotent stem cells
(Academic Press Inc Elsevier Science, 2011-07)
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are a promising source of cells for regenerative medicine because of their potential of self renew and differentiation. Multiple evidences highlight ...
Pluripotent Reprogramming of Fibroblasts by Lentiviralmediated Insertion of SOX2, C-MYC, and TCL-1A
(MARY ANN LIEBERT INC, 2011)
Reprogramming of somatic cells to pluripotency promises to boost cellular therapy. Most instances of direct reprogramming have been achieved by forced expression of defined exogenous factors using multiple viral vectors. ...
The pluripotency transcription factor Nanog represses glutathione reductase gene expression in mouse embryonic stem cells
(BioMed Central, 2019-07)
Objective: Redox homeostasis maintenance is essential to bring about cellular functions. Particularly, embryonic stem cells (ESCs) have high fidelity mechanisms for DNA repair, high activity of different antioxidant enzymes ...
Pluripotent stem cell transcription factors during human odontogenesis
(Springer, 2013-09-01)
Stem cells are capable of generating various cell lines and can be obtained from adult or embryonic tissues for clinical therapies. Stem cells from deciduous dental pulp are among those that are easily obtainable from adult ...