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Pleiotropic effects of statins on brain cells
(Elsevier Science, 2020-09)
Starting with cholesterol homeostasis, the first part of the review addresses various aspects of cholesterol metabolism in neuronal and glial cells and the mutual crosstalk between the two cell types, particularly the ...
The Dual Role of Senescence in Tumorigenesis
(Sociedad Chilena de Anatomía, 2010)
AHAS Trp574Leu substitution in Raphanus sativus L.: screening, enzyme activity and fitness cost
(John Wiley & Sons Ltd, 2018-01-03)
Feral radish (Raphanus sativus L.) is a problematic weed that has become resistant to acetohydroxyacid synthase (AHAS) inhibitor herbicides due to the Trp574Leu mutation. An AHAS gene mutation that causes herbicide resistance ...
Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity
(Elsevier Science London, 2019-06)
The current paradigm in the field of gene regulation postulates that regulatory information for generating gene expression is organized into modules (enhancers), each containing the information for driving gene expression ...
ALS herbicide resistance mutations in Raphanus raphanistrum: Evaluation of pleiotropic effects on vegetative growth and ALS activity
(Wiley, 2013-06)
Background
Gene mutations that endow herbicide resistance may cause pleiotropic effects on plant ecology and physiology. This paper reports on the effect of a number of known and novel target-site resistance mutations of ...
Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty
(2020-06-10)
Statins are a class of drugs that act lowering lipid levels by inhibiting cholesterol biosynthesis. Additionally, statins can act by “pleiotropic effects”, related to the inhibition of synthesis of the other mevalonate ...
Genome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseasesGenome-wide association study of liver-related enzymes suggests putative pleiotropic effects on diverse traits and diseases
(John Wiley & Sons Inc.John Wiley & Sons Inc., 2021-12)
Over the last decade, genome-wide association studies (GWAS) have allowed for the dissection of the genetic susceptibility to complex liver diseases.(1) In a recent issue of Nature communications, Chen et al. conducted a ...
Pleiotropic effects of atorvastatin in heart failure: role in oxidative stress, inflammation, endothelial function, and exercise capacity
(2008)
BACKGROUND:Increased oxidative stress, a common feature in chronic heart failure, has been associated with inflammation, endothelial dysfunction, and extracellular matrix degradation. Statins have known anti-inflammatory ...