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Centella asiatica water extract inhibits iPLA(2) and cPLA(2) activities in rat cerebellum
(ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2008)
Centella asiatica (L.) Urb an is distributed widely in South America and Asia and is known as a therapeutic agent in folk medicine, capable of improving memory and treating several neurological disorders. Asiaticoside is ...
Intranasal delivery of zidovudine by PLA and PLA-PEG blend nanoparticles
(Elsevier B.V., 2010-08-16)
This study describes the preparation and evaluation of biodegradable poly(L-lactide) (PLA) and poly(L, lactide)-poly(ethylene glycol) (PLA-PEG) blend nanoparticles containing zidovudine as model drug. The prepared nanoparticles ...
Modificação química de poli(ácido láctico) com anidrido maleico por processamento reativo
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-graduação em Ciência e Engenharia de Materiais, 2014-08-18)
The chemical modification of PLA with maleic anhydride by reactive processing and the extent of reaction and degradation reactions, were studied. Routes of grafting reaction of maleic anhydride in PLA were evaluated. Dicumyl ...
Neutralisation of the pharmacological activities of Bothrops alternatus venom by anti-PLA2 IgGs
(Elsevier, 2014-05)
Basic phospholipases A2 (PLA2) are toxic and induce a wide spectrum of pharmacological effects, although the acidic enzyme types are not lethal or cause low lethality. Therefore, it is challenging to elucidate the mechanism ...
A structure based model for liposome disruption and the role of catalytic activity in myotoxic phospholipase A(2)S
(Elsevier B.V., 2003-12-15)
Venom phospholipase A(2)s (PLA(2)s) display a wide spectrum of pharmacological activities and, based on the wealth of biochemical and structural data currently available for PLA(2)S, mechanistic models can now be inferred ...
A radioenzymatic assay to identify three groups of phospholipase A(2) in platelets
(ELSEVIER SCI LTDOXFORD, 2012)
Phospholipases A(2) (PLA(2)) are key enzymes in membrane metabolism. The release of fatty acids and lysophospholipids by PLA(2) activates several intra-cellular second messenger cascades that regulate a wide variety of ...
Effect of the synthetic coumarin, ethyl 2-oxo-2H-chromene-3-carboxylate, on activity of Crotalus durissus ruruima sPLA2 as well as on edema and platelet aggregation induced by this factor
(Pergamon-Elsevier B.V. Ltd, 2010-07-01)
We show that ethyl 2-oxo-2H-chromene-3-carboxylate (EOCC), a synthetic coumarin, irreversibly inhibits phospholipase A(2) (sPLA2) from Crotalus durissus ruruima venom (sPLA2r) with an IC(50) of 3.1 +/- 0.06 nmol. EOCC ...
Umbelliferone induces changes in the structure and pharmacological activities of Bn IV, a phospholipase A(2) isoform isolated from Bothrops neuwiedi
(Pergamon-Elsevier B.V. Ltd, 2011-05-01)
In this paper was demonstrated that umbelliferone induces changes in structure and pharmacological activities of Bn IV, a lysine 49 secretory phospholipase A(2) (sPLA2) from Both tops neuwiedi. Incubation of Bn IV with ...
Biocompatibilidade do biopolímero PLA e blenda PLA/PCL em ratos Wistar
(Universidade Estadual Paulista (UNESP), 2019-02-22)
A descoberta de polímeros biodegradáveis influenciou a pesquisa biomédica. O poli (ácido lático) (PLA) e a Poli (Ɛ-caprolactona) (PCL) e suas blendas se tornaram foco de vários estudos por serem biodegradáveis e ...