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Molecular and cellular pathogenesis of pituitary tumors
(Elsevier, 2018-08)
Pituitary tumors occur sporadically (95%) or as hereditary tumors, either associated with endocrine syndromes (2.5%) or as familial isolated variants (FIPA, 2.5%). In sporadic pituitary tumors, in addition to the known ...
Changes of stem cell niche during experimental pituitary tumor development
(Wiley Blackwell Publishing, Inc, 2021-10)
To investigate the putative stem cell/tumor stem cell (SC/TSC) niche contribution to hyperplasic/adenomatous pituitary lesions, we analyzed variation in the pituitary stem cell population during the development of experimental ...
Cell life and death in the anterior pituitary gland: role of oestrogens
(Wiley, 2010-07)
Apoptotic processes play an important role in the maintenance of cell numbers in the anterior pituitary gland during physiological endocrine events. In this review, we summarise the regulation of apoptosis of anterior ...
Programmed cell senescence: Role of IL-6 in the pituitary
(BioScientifica, 2017-05)
IL-6 is a pleiotropic cytokine with multiple pathophysiological functions. As a key factor of the senescence secretome, it can not only promote tumorigenesis and cell proliferation but also exert tumor suppressive functions, ...
Estradiol up-regulates c-FLIPlong expression in anterior pituitary cells
(Georg Thieme Verlag Kg, 2016-04)
Anterior pituitary cell turnover depends on a tight balance between proliferation and apoptosis. We have previously shown that estrogens sensitize anterior pituitary cells to pro-apoptotic stimuli. c-FLIP (cellular-FLICE ...
Estradiol Upregulates c-FLIPlong Expression in Anterior Pituitary Cells
(Georg Thieme Verlag Kg, 2016-04)
Anterior pituitary cell turnover depends on a tight balance between proliferation and apoptosis. We have previously shown that estrogens sensitize anterior pituitary cells to pro-apoptotic stimuli. c-FLIP (cellular-FLICE ...
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis
(Public Library Of Science, 2014-10)
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has ...
Effect of the photoperiod and administration of melatonin on folliculostellate cells of the pituitary pars distalis of adult male viscacha (Lagostomus maximus maximus)
(Elsevier Gmbh, Urban & Fischer Verlag, 2011-06)
Numerous reports have shown the effect of photoperiod and melatonin administration on the different hormone secreting cell types in the pituitary pars distalis. The viscacha (Lagostomus maximus maximus) is a rodent with ...
Perinatal DEHP exposure modulates pituitary estrogen receptor α and β expression altering lactotroph and somatotroph cell growth in prepuberal and adult male rats
(Pergamon-Elsevier Science Ltd, 2021-12)
Phthalates are synthetic chemicals widely used to make polyvinylchloride (PVC) soft and flexible. Of these, Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used, with high human exposure occurring as early as the ...
Adrenocorticotropin-producing pituitary carcinoma with expression of c-erbB-2 and high PCNA index: A comparative study with pituitary adenomas and normal pituitary tissues
(Humana Press Inc, 1998-03-01)
Pituitary carcinomas are very rare neoplasms with a poor prognosis. We report a case of Cushing's disease resulting from a pituitary carcinoma in a ZZ-yr-old female, who died of massive hepatic failure. At autopsy, there ...