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PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome
(2018-12-29)
Background: Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are ...
Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas
(Associação Brasileira de Divulgação Científica, 2012)
The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding ...
Orofacial overgrowth with peripheral nerve enlargement and perineuriomatous pseudo-onion bulb proliferations is part of the PIK3CA-related overgrowth spectrum
(2020-10-22)
Individuals with orofacial asymmetry due to mucosal overgrowths, ipsilateral bone and dental aberrations with perineurial hyperplasia and/or perineuriomatous pseudo-onion bulb proliferations, comprise a recognizable clinical ...
Analysis of mutations in the PIK3CA and FGFR3 genes in verrucous epidermal nevusAnálise de mutações nos genes PIK3CA e FGFR3 em caso de nevo epidérmico verrucoso
(Sociedade Brasileira de Dermatologia, 2023)
PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients
(HOSPITAL CLINICAS, UNIV SAO PAULOSAO PAULO, 2012)
OBJECTIVES: The phosphatidylinositol 3-kinase/AKT axis is an important cell-signaling pathway that mediates cell proliferation and survival, two biological processes that regulate malignant cell growth. The phosphatidylinositol ...
Case report: metaplastic breast carcinoma with pure squamous epithelial component and PIK3CA mutationReporte de caso: carcinoma metaplásico de mama con componente epitelial escamoso puro y mutación de PIK3CA
(Editorial Ciencia digital Registrada en la Cámara Ecuatoriana del Libro No Afiliación 663 (Editor DrC. Efraín Velasteguí López. PhD.), 2023)