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PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

Barretos Cancer Hospital; Federal University of Triangulo Mineiro; Universidade Estadual Paulista (Unesp); Universidade de São Paulo (USP); University of Minho; ICVS/3B's - PT Government Assoc. Lab. (2018-12-29)

Background: Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are ...

Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

Murat, C.B.; Braga, P.B.S.; Fortes, M.A.H.Z.; Bronstein, M.D.; Corrêa-Giannella, M.L.C.; Giorgi, R.R. (Associação Brasileira de Divulgação Científica, 2012)

The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding ...

Orofacial overgrowth with peripheral nerve enlargement and perineuriomatous pseudo-onion bulb proliferations is part of the PIK3CA-related overgrowth spectrum

University of Minnesota; Universidade Estadual Paulista (UNESP); King Saud University; National Human Genome Research Institute; University of Pennsylvania Perelman School of Medicine (2020-10-22)

Individuals with orofacial asymmetry due to mucosal overgrowths, ipsilateral bone and dental aberrations with perineurial hyperplasia and/or perineuriomatous pseudo-onion bulb proliferations, comprise a recognizable clinical ...

Mutation profiling in the PIK3CA, TP53, and CDKN2A genes in circulating free DNA and impalpable breast lesions

Delmonico, Lucas; Costa, Maurício Augusto Silva Magalhães; Fournier, Marcia Vasconcellos; Romano, Sérgio de Oliveira; Nascimento, Cristina Moreira do; Barbosa, Andréia Soares; Moreira, Aline dos Santos; Scherrer, Luciano Rios; Ornellas, Maria Helena Faria; Alves, Gilda (Elsevier 12 Months, 2019)

Analysis of mutations in the PIK3CA and FGFR3 genes in verrucous epidermal nevusAnálise de mutações nos genes PIK3CA e FGFR3 em caso de nevo epidérmico verrucoso

Miranda, Ludmilla Queirós; Fracaroli, Tainá Scalfoni; Fonseca, João Carlos Macedo; Fontenelle, Elisa; Curvo, Raphael Pedro Machado; Porto, Luís Cristóvão; Souto, Roberto (Sociedade Brasileira de Dermatologia, 2023)

PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients

Mangone, Flavia R.; Bobrovnitchaia, Irina G.; Salaorni, Sibeli; Manuli, Erika; Nagai, Maria A. (HOSPITAL CLINICAS, UNIV SAO PAULOSAO PAULO, 2012)

OBJECTIVES: The phosphatidylinositol 3-kinase/AKT axis is an important cell-signaling pathway that mediates cell proliferation and survival, two biological processes that regulate malignant cell growth. The phosphatidylinositol ...

DMBA induced mouse mammary tumors display high incidence of activating Pik3ca<sup>H1047</sup> and loss of function Pten mutations

Abba, Martín Carlos; Zhong, Yi; Lee, Jaeho; Kil, Hyunsuk; Lu, Yue; Takata, Yoko; Simper, Melissa S.; Gaddis, Sally; Shen, Jianjun; Aldaz, C. Marcelo (2016)

Activating pik3ca somatic mutation in congenital unilateral isolated muscle overgrowth of the upper extremity

Autor desconocido (WILEY-LISS, 2014)

Caracterización de variantes patogénicas en el gen PIK3CA en anomalías vasculares complejas

Hernández Hernández, Alejandra (2023)

Case report: metaplastic breast carcinoma with pure squamous epithelial component and PIK3CA mutationReporte de caso: carcinoma metaplásico de mama con componente epitelial escamoso puro y mutación de PIK3CA

León Crespo, Karen Vanessa; Coronel Montero, Jorge Sebastián; León Crespo, Kevin Sebastián (Editorial Ciencia digital Registrada en la Cámara Ecuatoriana del Libro No Afiliación 663 (Editor DrC. Efraín Velasteguí López. PhD.), 2023)

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