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Fra-1 and c-Fos N-terminal deletion mutants impair breast tumor cell proliferation by blocking lipid synthesis activation
(Frontiers Media S.A., 2019-06)
Tumor cells require high rates of lipid synthesis to support membrane biogenesis for their exacerbated growth. The only two proteins known that activate phospholipid synthesis are Fra-1 and c-Fos, two members of the AP-1 ...
Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration
(2013-01-01)
Retinopathy, a common complication of diabetes, is characterized by an unbalanced production of nitric oxide (NO), a process regulated by nitric oxide synthase (NOS). We hypothesized that retinopathy might stem from changes ...
Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration
(2013-01-01)
Retinopathy, a common complication of diabetes, is characterized by an unbalanced production of nitric oxide (NO), a process regulated by nitric oxide synthase (NOS). We hypothesized that retinopathy might stem from changes ...
Regulation of Cbl-associated protein/Cbl pathway in muscle and adipose tissues of two animal models of insulin resistance
(Endocrine SocBethesdaEUA, 2004)
Effect of thiopental, pentobarbital and diethyl ether on early steps of insulin action in liver and muscle of the intact rat
(Pergamon-elsevier Science LtdOxfordInglaterra, 2005)
Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway
(ELSEVIER SCIENCE INCNEW YORK, 2012)
Nitroglycerin (GIN) has been clinically used to treat angina pectoris and acute heart episodes for over 100 years. The effects of GTN have long been recognized and active research has contributed to the unraveling of ...
Defects in insulin signal transduction in liver and muscle of pregnant rats
(Springer VerlagNew York, 1997)