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A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2014)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(2013-01-01)
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...
A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2015)
A review of pharmacokinetic parameters of metabolites and prodrugs
(Drug Metabolism Letters, 2015)
Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging
(2019-07-01)
In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic ...
Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing
(Elsevier, 2020-12-01)
SARS-CoV-2 utilizes the IMPα/β1 heterodimer to enter host cell nuclei after gaining cellular access through the ACE2 receptor. Ivermectin has shown antiviral activity by inhibiting the formation of the importin-α (IMPα) ...
Clinical Pharmacokinetics of Intra-arterial Melphalan and Topotecan Combination in Patients with Retinoblastoma
(Elsevier, 2014-04)
Purpose: To assess the antitumor activity, toxicity, and plasma pharmacokinetics of the combination of
melphalan and topotecan for superselective ophthalmic artery infusion (SSOAI) treatment of children with
retinoblas ...
Assessment of an anti-ageing structured cosmetic formulation containing goji berry
(2019-01-01)
Based on previous studies, it has been found that goji berry (GB), popularly known as a ‘miracle fruit’, has excellent antioxidant potential and can be used in the treatment of skin disorders associated with ageing. This ...
Pharmacokinetic properties and in silico ADME modeling in drug discovery
(Bentham ScienceBussum, 2013-03)
The discovery and development of a new drug are time-consuming, difficult and expensive. This complex process has evolved from classical methods into an integration of modern technologies and innovative strategies addressed ...
Assessment of the physicochemical properties and stability for pharmaco-kinetic prediction of pyrazinoic acid derivatives
(2020-01-01)
Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which still has high prevalence worldwide. In addition, cases of drug resistance are frequently observed. In the search for new ...