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Structure activity relationships and the binding mode of quinolinone-pyrimidine hybrids as reversal agents of multidrug resistance mediated by P-gp
(Nature Publishing Group, 2021-08)
P-gp-associated multidrug resistance is a major impediment to the success of chemotherapy. With the aim of finding non-toxic and effective P-gp inhibitors, we investigated a panel of quinolin-2-one-pyrimidine hybrids. Among ...
Drug Transporters
(Springer Nature Switzerland AG, 2018)
Membrane transporters perform a central function in many essential body functions, including traffic and compartmentalization of physiologic compounds, absorption of physiologic compounds (and, occasionally, structurally ...
Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats
(Elsevier Ireland, 2017-09)
Multidrug resistance-associated protein 2 (Mrp2, ABCC2) and P-glycoprotein (P-gp, ABCB1) constitute essential components of the intestinal biochemical barrier that prevent incorporation of food contaminants, drugs or toxic ...
Expression of multidrug resistance proteins in prostate cancer is related with cell sensitivity to chemotherapeutic drugs
(2009)
BACKGROUND. Multidrug resistance (MDR) proteins have been associated with the lack of chemotherapy response. Expression of these proteins has been described in the prostate, but there is no information about their role in ...
Associação entre polimorfismos no gene da glicoproteína-P (PgP) e resistência múltipla a anti-helmínticos em Haemonchus contortus e identificação de fatores de risco relacionados
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEv, 2014-02-28)
Among the sheep parasites, Haemonchus contortus is the most prevalent and pathogenic nematode in tropical areas, causing huge economic losses. Alterations in the gene encoding the membrane P-glycoprotein (PgP) have been ...
Expression of P-glycoprotein, multidrug resistance-associated protein, glutathione-S-transferase pi and p53 in canine transmissible venereal tumor
(Colégio Brasileiro de Patologia Animal - CBPA, 2014-01-01)
The overexpression of proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP1), mutant p53, and the enzyme glutathione-S-transferase (GSTpi) are related to resistance to chemotherapy in neoplasms. ...
Plant extracts and betulin from Ligaria cuneifolia inhibit P-glycoprotein function in leukemia cells
(Pergamon-Elsevier Science Ltd, 2020-12)
Overexpression of P-glycoprotein (P-gp), which is linked to multidrug resistance (MDR), is one of the underlying obstacles to the success of chemotherapy as it reduces the efficacy of anticancer drugs and the side effects ...
Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative
(Frontiers, 2017-04)
P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders ...
Development of a highly specific ensemble of topological models for early identification of P-glycoprotein substrates
(John Wiley & Sons Ltd, 2011-06)
P-glycoprotein (Pgp) is an ATP-dependent efflux transporter protein associated with multidrug resistance in several diseases such as cancer, epilepsy and AIDS. It is preferentially expressed in organs and tissues that ...
Assessment of P-glycoprotein gene expression in adult stage of Haemonchus contortus in vivo exposed to ivermectin
(Elsevier Science, 2018-12)
The efflux transporter P-glycoprotein (P-gp) has been implicated in multidrug resistance of different nematode parasites affecting livestock species. Increased expression of P-gp in nematodes after their in vitro as well ...