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Overexpression of PGC-1α in aging muscle enhances a subset of young-like molecular patterns
(2018-04-01)
PGC-1α is a transcriptional co-activator known as the master regulator of mitochondrial biogenesis. Its control of metabolism has been suggested to exert critical influence in the aging process. We have aged mice overexpressing ...
Time-dependent effects of systemic lipopolysaccharide injection on regulators of antioxidant defense Nrf2 and PGC-1alpha in neonatal rat brain.
(Karger, 2013-04)
Background/Aims: Both excitotoxicity and neuroinflammation are associated with oxidative stress. One transcription factor, nuclear factor E2-related factor 2 (Nrf2), and one transcription cofactor, peroxisome proliferato ...
Aerobic exercise recovers disuse-induced atrophy through the stimulus of the LRP130/PGC-1α complex in aged rats
(2015)
Physical training has been shown to be important to the control of muscle mass during aging, through the activation of several pathways including, IGF1-AKT and PGC-1α. Also, it was demonstrated that LRP130, a component of ...
Docosahexaenoic acid-thyroid hormone combined protocol as a novel approach to metabolic stress disorders: Relation to mitochondrial adaptation via liver PGC-1α and sirtuin1 activation
(Blackwell Publishing Inc., 2019)
© 2018 International Union of Biochemistry and Molecular Biology Docosahexaenoic acid (DHA) and 3,3′,5-triiodothyronine (T 3 ) combined protocol affords protection against liver injury via AMPK signaling supporting energy ...
Differential regulation of PGC-1α expression in rat liver and skeletal muscle in response to voluntary running
(2010-04-30)
Abstract
Background
The beneficial actions of exercise training on lipid, glucose and energy metabolism and insulin sensitivity appear to be in part mediated by PGC-1α. Previous ...
Differential regulation of PGC-1α expression in rat liver and skeletal muscle in response to voluntary running
(2010-04-30)
Abstract
Background
The beneficial actions of exercise training on lipid, glucose and energy metabolism and insulin sensitivity appear to be in part mediated by PGC-1α. Previous ...
Estudio de las vías transduccionales que regulan la actividad metabólica de la testosterona a través de PGC-1α en cardiomiocitos
(Universidad de Chile, 2016)
El cardiomiocito, la célula contráctil del corazón, requiere el suministro continuo de energía para llevar a cabo la contracción muscular y sus diversos procesos celulares que incluyen sobrevida, crecimiento y metabolismo. ...
Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine
(Springer, 2013-04)
In this article, we review the current knowledge of and recent insights into the role of epigenetic factors in the development of insulin resistance (IR), with emphasis on peroxisome proliferator-activated receptor gamma ...
Differential regulation of PGC-1α expression in rat liver and skeletal muscle in response to voluntary running
(2010-04)
Abstract
Background
The beneficial actions of exercise training on lipid, glucose and energy metabolism and insulin sensitivity ...