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Implication of von Willebrand factor as a regulator of tumor cell metastasis: potential perioperative use of desmopressin and novel peptide analogs
(Karger, 2013-05)
Letter to the Editor
Use of desmopressin in children with inherited platelet dysfunctions undergoing adenotonsillar procedures
(2012)
INTRODUCTION AND GOALS:
Adenotonsillar surgery represents a major haemostatic challenge in paediatric patients with mild inherited platelet dysfunction. While there are recommendations for perioperative haemostatic ...
Desmopressin in canine mammary carcinoma: Comments on the importance of the administration route
(Wiley Blackwell Publishing, Inc, 2021-09)
Several years ago, we proposed the haemostatic peptide desmopressin (1-desamino-8-d-arginine vasopressin; dDAVP) as a potential anti-metastatic agent to be used during surgical excision of locally advanced tumours. A ...
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Colorectal Cancer: Potential use of Perioperative Desmopressin to Reduce Allogenic Blood Transfusion Rates
(Springer, 2017-11)
In the last decade, the correlation between cancer surgery outcome, disease recurrence, and patient survival with perioperative blood transfusion has been a topic of intense debate. In this regard, a large number of studies ...
Peri-operative biology in primary breast cancer: selective targeting of vasopressin type 2 receptor using desmopressin as a novel therapeutic approach
(Springer, 2016-06)
In breast cancer patients, surgical excision of the primary tumor is commonly the first step towards long-term control of disease progression. However, recent evidence suggests that surgery may also promote metastatic ...
Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells–Letter
(American Association for Cancer Research, 2016-08)
Blood-borne spread is responsible for the vast majority of cancer-related deaths, and it is recognized that clusters of circulating tumor cells (CTC) are much more likely to cause metastasis than single CTCs. In the November ...
A phase II dose-escalation trial of perioperative desmopressin (1-desamino-8-d-arginine vasopressin) in breast cancer patients
(Springer Open, 2015-12)
Desmopressin (dDAVP) is a well-known peptide analog of the antidiuretic hormone vasopressin, used to prevent excessive bleeding during surgical procedures. dDAVP increases hemostatic mediators, such as the von Willebrand ...
Commentary: Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer
(Frontiers Media, 2020-01-10)
Prostate cancer patients managed with androgen-deprivation therapy usually recur after a few years and the disease gradually becomes castration-resistant prostate cancer (CRPC). The role of tumor cell plasticity, including ...
Desmopressin inhibits lung and lymph node metastasis in a mouse mammary carcinoma model of surgical manipulation
(Wiley-liss, Div John Wiley & Sons Inc, 2002-09)
Background and Objectives: Desmopressin (DDAVP) is a synthetic derivative of vasopressin with hemostatic and fibrinolytic properties that has been used during surgery in patients with bleeding disorders. Our aim was to ...