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PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?
(Elsevier Science, 2010-04)
While many are the examples of DNA damaging treatments that induce p21 accumulation, the conception of p21 upregulation as the universal response to genotoxic stress has come to an end. Compelling evidences have demonstrated ...
Influence of melatonin and sexual hormones on the expression of proliferating cell nuclear antigen in the adrenal cortex of a seasonal breeder (Lagostomus maximus)
(Wiley-liss, div John Wiley & Sons Inc., 2020-12)
The viscacha (Lagostomus maximus) is a rodent of nocturnal habits, whose physiology and behavior vary according to modifications of environmental signals. The objective of this study is to assess the influence of melatonin ...
CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication
(Molecular Diversity Preservation International, 2020-05)
p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor. CDK inhibition by p21 triggers ...
AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress
(Nature Publishing Group, 2019-05)
Translesion DNA synthesis (TLS) and homologous recombination (HR) cooperate during S-phase to safeguard replication forks integrity. Thus, the inhibition of TLS becomes a promising point of therapeutic intervention in ...
Valoración de la remodelación de las vellosidades placentarias porcinas a través de TUNEL y PCNAAssesment of porcine placental villi remodelling through TUNEL and PCNA
(Sociedad de Ciencias Morfológicas de La Plata, 2015)
El mantenimiento de la integridad estructural y funcional del tejido placentario involucra un recambio celular altamente regulado que depende de un delicado balance entre proliferación, diferenciación y pérdida celular. ...
The value of PCNA and AgNOR staining in endoscopic biopsies of gastric mucosa
(Gustav Fischer VerlagJenaAlemanha, 1998)
Avaliação da espermatogênese, níveis plasmáticos de esteroides sexuais e expressão de HSP70, PCNA e caspase-3 em Prochilodus argenteus: um estudo comparativo em dois pontos do rio São Francisco, a jusante da barragem de Três Marias
(Universidade Federal de Minas GeraisUFMG, 2012-08-27)
The testicular development and maturation of fish are regulated by sex hormones that influence the processes of proliferation and cell death of germ and somatic cells. The stress caused by changes in environmental conditions ...
Effect of a half dose of tamoxifen on proliferative activity in normal breast tissue
(Elsevier B.V., 1999-10-01)
Objectives: To investigate the proliferative activity of the mammary gland epithelium and plasma levels of progesterone, estradiol, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and sex hormone-binding ...
Mouriri elliptica: Validation of gastroprotective, healing and anti-Helicobacter pylori effects
(Elsevier B.V., 2009-06-25)
Ethnopharmacological relevance: Mouriri elliptica Martius (Melastomataceae) is species reputed in folk medicine to heal gastric ulcer and gastritis.Aim of the study: Methanolic extract (ME) and ethyl acetate fraction (EAF) ...
Mouriri elliptica: Validation of gastroprotective, healing and anti-Helicobacter pylori effects
(Elsevier B.V., 2009-06-25)
Ethnopharmacological relevance: Mouriri elliptica Martius (Melastomataceae) is species reputed in folk medicine to heal gastric ulcer and gastritis.Aim of the study: Methanolic extract (ME) and ethyl acetate fraction (EAF) ...