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Paracoccidioides brasiliensis induces cytokine secretion in epithelial cells in a protease-activated receptor-dependent (PAR) manner
(Springer, 2017)
Paracoccidioides brasiliensis is one of the etiological agents of the human systemic mycosis paracoccidioidomycosis. Protease-activated receptors (PARs) are expressed in many cell types and comprise a family of G protein-coupled ...
Influence of Parstatin on Experimental Periodontal Disease and Repair in Rats
(Amer Acad Periodontology, 2014-09-01)
Background: Parstatin is a 41-amino acid peptide, formed by proteolytic cleavage on activation of the protease activated receptor-1, with antiangiogenic properties. The purpose of this study is to evaluate the influence ...
Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain
(Elsevier B.V., 2007-03-02)
Chronic exposure to Cannabis sativa (marijuana) produced a significant down-regulation of cannabinoid receptor in the postmortem human brain. the significant decrease in maximal binding capacity was not accompanied by ...
Periodontal treatment downregulates protease-activated receptor 2 in human gingival crevicular fluid cells
(American Society for MicrobiologyBethesda, 2013-12)
Protease-activated receptor 2 (PAR2) is implicated in the pathogenesis of chronic inflammatory diseases, including periodontitis; it can be activated by gingipain and produced by Porphyromonas gingivalis and by neutrophil ...
Influence of Parstatin on Experimental Periodontal Disease and Repair in Rats
(Amer Acad Periodontology, 2015)
Influence of Parstatin on Experimental Periodontal Disease and Repair in Rats
(Amer Acad Periodontology, 2015)
The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR(2))
(Nature Publishing Group, 2006-10-01)
Background and purpose: S100A9 protein induces anti-nociception in rodents, in different experimental models of inflammatory pain. Herein, we investigated the effects of a fragment of the C-terminus of S100A9 (mS100A9p), ...
Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis
(Nature Publishing Group, 2015-01-15)
The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis. Furthermore, matriptase is unique among ...
Evidence for increased expression of tissue factor and protease-activated receptor-1 in human esophageal cancer
(Spandidos Publ LtdAthensGrécia, 2009)
Substrate specificity of human kallikrein 6 - Salt and glycosaminoglycan activation effects
(Amer Soc Biochemistry Molecular Biology Inc, 2006-02-10)
Human kallikrein 6 ( hK6) is abundantly expressed in the central nervous system and is implicated in demyelinating disease. This study provided biochemical data about the substrate specificity and activation of hK6 by ...