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Investigation of Thrombin Activity with PAR 1-based Fluorogenic Peptides
(Bentham Science Publ Ltd, 2013-10-01)
Thrombin, a highly specific protease of blood coagulation, has two exosites that modulate its specificity. We designed two sets of synthetic substrate FRET peptides with 25- or 11-amino acids (aa) each, based on the PAR 1 ...
Effect of a thrombin receptor (protease-activated receptor 1, PAR-1) gene polymorphism in chronic hepatitis C liver fibrosis
(WILEY-BLACKWELL, 2008)
Background and Aim: Tissue injury leads to activation of coagulation and generation of thrombin. Inhibition of thrombin receptor protease-activated receptor 1 (PAR-1) has been shown to reduce liver fibrosis in animals. ...
Platelet protease-activated receptor 1 and membrane expression of P-selectin in pulmonary arterial hypertension
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
Introduction: Pulmonary arterial hypertension (PAH) is frequently associated with thrombotic events, particularly involving the pulmonary microcirculation at sites of vascular injury. We therefore decided to analyse ...
O papel profilático do exercício físico sobre a modulação neurovascular e os efeitos da trombina no desenvolvimento de convulsões pós-traumáticas
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2021-08-30)
Traumatic brain injury (TBI) is considered a worldwide public health problem due to its high incidence and high public costs. Although the pathophysiology of TBI is multifaceted, the occurrence of coagulopathy is strongly ...
Enzyme specificity and effects of gyroxin, a serine protease from the venom of the South American rattlesnake Crotalus durissus terrificus, on protease-activated receptors
(Elsevier B.V., 2014-03-01)
Gyroxin is a serine protease displaying a thrombin-like activity found in the venom of the South American rattlesnake Crotalus durissus terrificus. Typically, intravenous injection of purified gyroxin induces a barrel ...
Expression of Protease Activated Receptor-1 in Chronic Periodontitis
(Amer Acad Periodontology, 2014-12-01)
Background: Protease activated receptor-1 (PAR(1)) activation by thrombin may play a role in repair and homeostasis of periodontal tissues. The main objective of this study is to investigate PAR(1) expression in patients ...
Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011)
Protease-activated receptor 1 (PAR-1) is a G-protein-coupled receptor that is overexpressed in solid tumors, being associated with several pro-tumoral responses including primary growth, invasion, metastasis and angiogenesis. ...
Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1
(BIOSCIENTIFICA LTD, 2012)
Progesterone and progestins have been demonstrated to enhance breast cancer cell migration, although the mechanisms are still not fully understood. The protease-activated receptors (PARs) are a family of membrane receptors ...
Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
(Massachussetts Medical Society, 2012)
BACKGROUND: Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS: In this multinational, double-blind, randomized trial, we compared vorapaxar ...