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Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis

Zunino, Rodolfo; Li, Qinggang; Rosé, Sergio Daniel; Romero-Benítez, María Margarita Itatí; Lejen, Tatiana; Brandan, Nora Cristina; Trifaró, José-María (American Society of Hematology, 2001-10)

Rapid proliferation of atypical megakaryoblasts is a characteristic of megakaryoblastic leukemia. Cells from patients with this disorder and cell lines established from this type of leukemia showed the presence of gelsolin ...