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The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity
(Elsevier Science, 2015-07)
P-type ion pumps are membrane transporters that have been classified into five subfamilies termed P1-P5. The ion transported by the P5-ATPases is not known. Five genes named ATP13A1-ATP13A5 that belong to the P5-ATPase ...
The Human P5B-ATPase ATP13A2 is not a Ca2+ Transporting Pump
(David Publishing Company, 2011-01)
The human gene ATP13A2 has been proposed to code for an ATP powered ion transporter of the P5B subfamily. Mutations of the human gene ATP13A2 were found to underlie an autosomal recessive form of early-onset parkinsonism ...
Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line
(Elsevier, 2009-10)
Background: ATP exerts diverse effects on various cell types via speci fi c purinergic P2Y receptors. Intracellular signaling cascades are the main routes of communication between P2Y receptors and regulatory targets in ...
ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP
(Public Library Science, 2013-06-24)
In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed
human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished ...
Dynamic regulation of extracellular ATP in Escherichia coli
(Portland Press, 2017-04)
We studied the kinetics of extracellular ATP (ATPe) in Escherichia coli and their outer membrane vesicles (OMVs) stimulated with amphipatic peptides melittin (MEL) and mas-toparan 7 (MST7). Real-time luminometry was used ...
The strategic function of the P5-ATPase ATP13A2 in toxic waste disposal
(Pergamon-Elsevier Science Ltd, 2017-11)
The P-type ATPase ATP13A2 protein was originally associated with a form of Parkinson´s Disease (PD)known as Kufor Rakeb Syndrome (KRS). However, in the last years it has been found to underlay variantsof neuronal ...
Regulation of extracellular ATP in human erythrocytes infected with Plasmodium falciparum
(Public Library Of Science, 2014-05)
In human erythrocytes (h-RBCs) various stimuli induce increases in [cAMP] that trigger ATP release. The resulting pattern of extracellular ATP accumulation (ATPe kinetics) depends on both ATP release and ATPe degradation ...
Oral adenosine 5'-triphosphate supplementation improved hemodynamic and autonomic parameters after exercise in hypertensive women
(2018-08-01)
The aim of this study was to verify the autonomic modulation and blood pressure after adenosine-5'-triphosphate (ATP) supplementation asso-ciated to acute aerobic exercise in hypertensive women. Eleven hyper-tensive women ...
Parkinson's disease-associated human P5B-ATPase ATP13A2 increases spermidine uptake
(Portland Press, 2013-01)
P-type ion pumps are membrane transporters that have been classified into five subfamilies termed P1–P5. The ion transported by the P5-ATPases is not known. Five genes, ATP13A (ATPase type 13A) 1–ATP13A5, that belong to ...