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Metodologias para determinação da lipoproteína de baixa densidade oxidada (LDL-ox) como marcador de risco cardiovascular
(Universidade Federal de Santa MariaCentro de Ciências da Saúde, 2005)
Currently, the inflammatory disorders are believe to strongly correlate with
the condition of oxidative stress. Amongst them, one of the most studied is atherosclerosis.
Atherosclerosis is a disease of great world-wide ...
Pivotal Role for Platelet-Activating Factor Receptor in CD36 Expression and oxLDL Uptake by Human Monocytes/Macrophages
(KARGER, 2011)
The uptake of oxLDL by CD36 is not regulated by intracellular levels of cholesterol, leading to macrophage differentiation into foam cells which play a major role in atherosclerosis. Furthermore, oxLDL competes with PAF ...
Participación de lipoproteína de baja densidad oxidada (oxLDL) en la inducción de autofagia y sobrevida de miofibroblastos cardiacos
(Universidad de Chile, 2016)
Las enfermedades cardiovasculares (ECV) son la principal causa de muerte en el
mundo. Los elevados niveles de colesterol y lipoproteína de baja densidad (LDL), que se
han relacionado a un aumento de la cantidad de LDL ...
Hidrólise de nucleotídeos de adenina em plaquetas de pacientes com diferentes níveis de colesterol e sua relação com o processo inflamatório
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2006-10-10)
The activity of NTPDase (EC 3.6.1.5, apyrase, CD39) was verified in platelets from patients with increasing cholesterol levels. A possible association between cholesterol levels and inflammatory markers, such as oxidized ...
Oxidized low-density lipoproteins and their antibodies: Relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseases
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Background: Metabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial. Methods: In 107 adults without atherosclerotic manifestations, ...
Role of oxidized LDL-induced “trained macrophages” in the pathogenesis of COVID-19 and benefits of pioglitazone: A hypothesis
Background and aims: Older adults and people who have cardiovascular disorders (their common
pathogenetic mechanism is progressive atherosclerosis) are at higher risk for severe illness from COVID19 (coronavirus disease ...
Avaliação dos efeitos biomecânicos e funcionais da exposição de macrófagos às lipoproteínas nativas e oxidadas
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MORFOLOGIAPrograma de Pós-Graduação em Biologia CelularUFMG, 2020-02-28)
Atherosclerosis is chronic inflammatory disease characterised by the
formation of an atheromatous plaque that diminish the blood vessel lumen. The
plaque can also rupture and block small vessels, leading to complications ...
Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts
(Public Library of ScienceSan Francisco, 2013-10-09)
Macrophage interaction with oxidized low-density lipoprotein (oxLDL) leads to its differentiation into foam cells and cytokine production, contributing to atherosclerosis development. In a previous study, we showed that ...
Co-Stimulation of PAFR and CD36 Is Required for oxLDL-Induced Human Macrophages Activation
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
The oxidative process of LDL particles generates molecules which are structurally similar to platelet-activating factor (PAF), and some effects of oxidized LDL (oxLDL) have been shown to be dependent on PAF receptor (PAFR) ...