Buscar
Mostrando ítems 1-10 de 115
Adaptive evolution in mammalian proteins involved in cochlear outer hair cell electromotility
(Academic Press Inc Elsevier Science, 2006-12)
Somatic electromotility in cochlear outer hair cells, as the basis for cochlear amplification, is a mammalian novelty and it is largely dependent upon rapid cell length changes proposed to be mediated by the motor-protein ...
Spontaneous reversibility of damage to outer hair cells after sodium salicylate induced ototoxicity
(CAMBRIDGE UNIV PRESS, 2011)
Background: High sodium salicylate doses can cause reversible hearing loss and tinnitus, possibly due to reduced outer hair cell electromotility. Sodium salicylate is known to alter outer hair cell structure and function. ...
Functional postnatal maturation of the medial olivocochlear efferent-outer hair cell synapse
(Society for Neuroscience, 2020-06-17)
The organ of Corti, the auditory mammalian sensory epithelium, contains two types of mechanotransducer cells, inner and outer hair cells (IHCs and OHCs, respectively). IHCs are involved in conveying acoustic stimuli to the ...
Synaptic contributions to cochlear outer hair cell Ca2+ dynamics
(Society for Neuroscience, 2021-08)
For normal cochlear function, outer hair cells (OHCs) require a precise control of intracellular Ca21 levels. In the absence of regulatory elements such as proteinaceous buffers or extrusion pumps, OHCs degenerate, leading ...
Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians
(National Academy of Sciences, 2017-02)
The remarkable hearing capacities of mammals arise from various evolutionary innovations. These include the cochlear outer hair cells and their singular feature, somatic electromotility, i.e., the ability of their cylindrical ...
Editorial: Auditory Efferent System: New Insights from Cortex to Cochlea
(Frontiers Media, 2016)
Short-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells
(Society for Neuroscience, 2011-10)
In the mammalian inner ear, the gain control of auditory inputs is exerted by medial olivocochlear (MOC) neurons that innervate cochlear outer hair cells (OHCs). OHCs mechanically amplify the incoming sound waves by virtue ...
The α10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system
(National Academy of Sciences, 2007-12)
Although homomeric channels assembled from the α9 nicotinic acetylcholine receptor (nAChR) subunit are functional in vitro, electrophysiological, anatomical, and molecular data suggest that native cholinergic olivocochlear ...
Inner Hair Cell and Neuron Degeneration Contribute to Hearing Loss in a DFNA2-Like Mouse Model
(Pergamon-Elsevier Science Ltd, 2019-07-01)
DFNA2 is a progressive deafness caused by mutations in the voltage-activated potassium channel KCNQ4. Hearing loss develops with age from a mild increase in the hearing threshold to profound deafness. Studies using transgenic ...