Buscar
Mostrando ítems 1-10 de 17
Orthosteric and Allosteric Activation of Human 5-HT3A Receptors
(Cell Press, 2020-10-20)
The serotonin type 3 receptor (5-HT 3) is a ligand-gated ion channel that converts the binding of the neurotransmitter serotonin (5-HT) into a transient cation current that mediates fast excitatory responses in peripheral ...
Orthosteric and benzodiazepine cavities of the α1β2γ2 GABAA receptor: insights from experimentally validated in silico methods
(Adenine Press, 2019-05-04)
γ-aminobutyric acid-type A (GABA A ) receptors mediate fast synaptic inhibition in the central nervous system of mammals. They are modulated via several sites by numerous compounds, which include GABA, benzodiazepines, ...
Molecular basis of ligand dissociation in β-adrenergic receptors
(Public Library of Science, 2011)
The important and diverse biological functions of β-adrenergic receptors (βARs) have promoted the search for compounds to stimulate or inhibit their activity. In this regard, unraveling the molecular basis of ligand ...
Dibenzofuranylethylamines as 5-HT2A/2C receptor agonists
(American Chemical Society, 2020)
The human 5-HT2 receptor subtypes have high sequence identity in their orthosteric ligand-binding domain, and many agonists are poorly selective between the S-HT(2A )and 5-HT2C subtypes. Nevertheless, their activation is ...
New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists
(MDPI, 2021)
The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work ...
Molecular function of α7 nicotinic receptors as drug targets
(Wiley Blackwell Publishing, Inc, 2018-05-13)
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in many physiological and pathological processes. In vertebrates, there are seventeen different nAChR subunits that combine to ...
Modulación alostérica del Receptor de Glicina por Resveratrol.
(Universidad de ConcepciónFacultad de Ciencias Biológicas.Departamento de FisiologíaConcepción., 2023)
El receptor de glicina (RGli) pertenece a la familia de canales iónicos pentaméricos activados por ligando (pLGIC). El complejo funcional corresponde al ensamblaje de 5 subunidades formando un poro central, permeable a ...
Búsqueda de sitios de unión a ligandos en receptores nicotínicos de acetilcolina humano de tipo α7 y α4(2)β2(3)
(Universidad de Talca (Chile). Escuela de Bioinformática., 2014)