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Orexin A and B in vitro modify orexins receptors expression and Gonadotropins secretion of anterior pituitary cells of proestrous rats
(Elsevier Science, 2014-01)
Orexin A and orexin B (hypocretins) are neuropeptidessynthesized mainly by neurons located in the lateral hypothalamus andprojections throughout the brain. They are agonists at both the orexin 1and orexin 2 G protein-coupled ...
Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats
(2017)
Spontaneous physical activity (SPA) describes activity outside of formal exercise and shows large interindividual variability. The hypothalamic orexin/hypocretin peptides are key regulators of SPA. Orexins drive SPA within ...
Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal
(American Physiological Society, 2007-12)
Orexins and their receptors OX1 and OX2 regulate energy balance and the sleep-wake cycle. We studied the expression of prepro-orexin (PPO), OX1, and OX2 in brain and pituitary under the influence of the hormonal status in ...
Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat
(2011)
The 24-h distribution of rapid eye movement (REM) sleep is known to be deeply reshaped among albino rats with neurotoxic lesions in the lateral hypothalamus (LH) or among rodent models of human narcolepsy-cataplexy, with ...
Role of the orexin peptides in individual sensitivity to diet-induced obesity
(2014)
Chronic consumption of a high-fat diet leads to development of diet-inducedobesity (DIO) with significant variability in humans and rodents. This variability is associated with individual differences in intrinsic levels ...
Orexin in the toad Rhinella schneideri: The location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia
(Elsevier B. V., 2014-11-27)
Recent reports have suggested that orexins, also known as hypocretins, play an important role in the modulation of respiratory control in mammals, but there are no data available describing the role of the orexinergic ...
Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle. Effects of orexin receptor antagonists on gonadotropins and ovulation
(American Physiological Society, 2007-10)
Orexins are peptides controlling feeding, sleep, and neuroendocrine functions. They are synthesized by the hypothalamus with projections throughout the brain. Orexins and their orexin 1 (OX(1)) and orexin 2 receptors (OX(2)) ...
Orexin and neuropeptide Y: Tissue specific expression and immunoreactivity in the hypothalamus and preoptic area of the cichlid fish Cichlasoma dimerus
(Elsevier, 2013-12)
Neuropeptide Y (NPY) and orexin are neuropeptides involved in the regulation of feeding in vertebrates. In this study we determined the NPY and orexin mRNA tissue expression and their immunoreactivity distribution in both ...
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship
(Frontiers Research Foundation, 2012-11-22)
Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral (LH), perifornical, and dorsomedial (DMH) hypothalamus. These neurons innervate many regions in the brain and modulate multiple other ...