The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentanyl and morphine,whentwoofthemwere systemically combined in a 1:1 potency ratio, in the hot plate, the acetic acid writhing, ...

The purpose of the present study was to characterize the antinociceptive effects of tramadol, fentanyl and morphine, when two of them were systemically combined in a 1:1 potency ratio, in the hot plate, the acetic acid ...

Background: Opioids have been used for the management of pain and coadministration of two opioids may induce synergism. In a model of tonic pain, the acetic acid writhing test and in a phasic model, the hot plate, ...

Opioid analgesics are simultaneously indispensable medicines for the treatment of moderate to severe pain and are harmful when abused. The challenge for governments is to balance the obligation to prevent diversion, trafficking, ...

Los analgésicos opioides han demostrado ser una intervención efectiva en el control del dolor que no está desprovistos de riesgos. Con la declaración de la epidemia mundial de opioides se hizo clara la necesidad de vigilar ...

Opioid system, which involved endogenous opioid peptides and their receptors (Miu, Kappa, delta and ORL), has a main role in the physiology of several systems. At the same time, there is cumulating evidence in the role of ...

Objectives 1. Identify the attitudes and specific practices of general practitioners regarding opioid prescription. 2. Recognize general practitioners’ perceived barriers and facilitators of opioid prescription. 3. Describe ...

Pain is associated with emotional and physical suffering that severely impacts quality of life. Many guidelines for the treatment of moderate to severe cancer pain indicate the use of opioids. For a small proportion of the ...

Latin America consumes less than 2.7% of the morphine in the world, as reported by the governments to the International Narcotics Control Board. Methods to improve access to opioids for the treatment of pain have been ...