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The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice
(Wiley Blackwell Publishing, Inc, 2001-03)
According to the dual systems model for opiate reward, dopamine mediates opiate motivation when an animal is in a deprived motivational state (i.e. opiate-dependent and in withdrawal) and not when an animal is in a nondeprived ...
Previous spatial learning is required for the development of place preference in rats following chronic administration of and withdrawal from morphine
(Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, 2009)
The positive reinforcing properties of addictive drugs have a primary role in the development of drug dependence. In the field of opiates, great attention has been given to this phenomenon, as well as to the negative ...
Baclofen did not modify sexually dimorphic c-Fos expression during morphine withdrawal syndrome
(Wiley, 2013-03)
In previous studies, we have reported sex-related differences during morphine withdrawal. We have also shown that the GABAB agonist baclofen (BAC) was able to prevent the morphine withdrawal syndrome in male as well as in ...
Baclofen prevents the elevated plus maze behavior and BDNF expression during naloxone precipitated morphine withdrawal in male and female mice
(Wiley-liss, Div John Wiley & Sons Inc, 2016-05)
In previous studies we have shown that baclofen, a selective GABAB receptor agonist, prevents the somatic expression and reestablishes the dopamine and μ-opioid receptors levels, modified during naloxone-precipitated ...
Involvement of the midbrain tectum in the unconditioned fear promoted by morphine withdrawal
(ELSEVIER SCIENCE BV, 2008)
The midbrain rectum structures, dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), are involved in the organization of fear and anxiety states during the exposure to dangerous stimuli. Since opiate withdrawal ...
Anxiety-like symptoms induced by morphine withdrawal may be due to the sensitization of the dorsal periaqueductal grey
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Withdrawal from morphine leads to the appearance of extreme anxiety accompanied of several physical disturbances, most of them linked to the activation of brainstem regions such as the locus coeruleus, ventral tegmental ...
Síndrome das pernas inquietas: Diagnóstico e tratamento. Opinião de especialistas Brasileiros
(2007-09-01)
This article contains the conclusions of the November 17-18, 2006 meeting of the Brazilian Study Group of Restless Legs Syndrome (GBE-SPI) about diagnosis and management of restless legs syndrome (RLS). RLS is characterized ...
Síndrome das pernas inquietas: Diagnóstico e tratamento. Opinião de especialistas Brasileiros
(2007-09-01)
This article contains the conclusions of the November 17-18, 2006 meeting of the Brazilian Study Group of Restless Legs Syndrome (GBE-SPI) about diagnosis and management of restless legs syndrome (RLS). RLS is characterized ...
Morphine withdrawal syndrome and its prevention with baclofen: Autoradiographic study of μ‐opioid receptors in prepubertal male and female mice
(Wiley-liss, Div John Wiley & Sons Inc, 2006-07)
Although the expression of the morphine (MOR) withdrawal syndrome is more marked in male mice than in females, we have demonstrated that the GABAB agonist baclofen (BAC) is able to attenuate MOR withdrawal signs in either ...
Disparate spinal and supraspinal opioid antinociceptive responses in β-endorphin-deficient mutant mice
(Pergamon-Elsevier Science Ltd, 2000-11)
The role of endogenous opioid systems in the analgesic response to exogenous opiates remains controversial. We previously reported that mice lacking the peptide neurotransmitter β-endorphin, although unable to produce ...