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Progress in the use of antisense oligonucleotides for vaccine improvement
(2020-02-01)
Antisense oligonucleotides (ASOs) are synthetically prepared short single-stranded deoxynucleotide sequences that have been validated as therapeutic agents and as a valuable tool in molecular driving biology. ASOs can block ...
Targeting kupffer cells with antisense oligonucleotides
(Frontiers in Bioscience, 2002)
© 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in ...
Tetranucleotide ggga motif primary transcripts: novel target site for antisense design
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 1998)
Selecting effective antisense target sites on a given mRNA molecule constitutes a major problem in antisense therapeutics. By trial-and-error, only 1 in 18 (6%) of antisense oligonucleotides designed to target the primary ...
Tetranucleotide GGGA motif in primary RNA transcripts: Novel target site for antisense design
(1998)
Selecting effective antisense target sites on a given mRNA molecule constitutes a major problem in antisense therapeutics. By trial-and-error, only 1 in 18 (6%) of antisense oligonucleotides designed to target the primary ...
Prevention of renal ischemic reperfusion injury using fty 720 and icam-1 antisense oligonucleotides
(ELSEVIER SCIENCE INC., 2003)
Tetranucleotide ggga motif primary transcripts: novel target site for antisense designTHE JOURNAL OF BIOLOGICAL CHEMISTRY (IMPRESA)J. Biol. Chem.
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017)
A Comprehensive Haplotype Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
(Elsevier, 2019)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a gain-of-function mutation in HTT. Suppression of mutant HTT has emerged as a leading therapeutic strategy for HD, with allele-selective approaches ...
Identification of sense and antisense transcripts regulated by drought in sugarcane
(SPRINGERDORDRECHT, 2012-07)
Sugarcane is an important sugar and energy crop that can be used efficiently for biofuels production. The development of sugarcane cultivars tolerant to drought could allow for the expansion of plantations to sub-prime ...