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Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
(BioMed Central, 2011-10)
Background: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important ...
Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
(Informa Healthcare, 2019)
Effects of the herbicide glyphosate on non-target plant native species from Chaco forest (Argentina)
(Academic Press Inc Elsevier Science, 2017-10)
Agriculture based on transgenic crops has expanded in Argentina into areas formerly occupied by Chaco forest. Even though glyphosate is the herbicide most widely used in the world, increasing evidence indicates severe ...
Bacille Calmette Guérin (BCG) and new TB vaccines: specific, cross-myco‐ bacterial and off-target effects
The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected ...
(off) Targeting UPR signaling: the race toward intervening ER proteostasis
(Taylor & Francis, 2018)
(off)Targeting UPR signaling: the race toward intervening ER proteostasis
(Taylor and Francis Ltd, 2018)