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Metformin has a direct effect on ovarian cells that is dependent on organic cation transporters
(Elsevier Ireland, 2020-01)
Metformin (MET) is the most widely prescribed hypoglycemic drug in type 2 diabetes and Polycystic Ovary Syndrome. Besides its effects on glucose metabolism, MET exerts beneficial effects on these patients? fertility. ...
Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages
(Elsevier Science, 2014-04)
We have previously described that arachidonic acid (AA)-5-lipoxygenase (5-LO) metabolism inhibitors such as NDGA and MK886, inhibit cell death by apoptosis, but not by necrosis, induced by extracellular ATP (ATPe) binding ...
Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations
(2020-08-01)
Gabapentin (GBP) is an organic cation mainly eliminated unchanged in urine, and active drug secretion has been suggested to contribute to its renal excretion. Our objective was to evaluate the potential drug-drug interaction ...
Acute infusion of angiotensin II regulates organic cation transporters function in the kidney: its impact on the renal dopaminergic system and sodium excretion
(Nature Publishing Group, 2020-09)
A close relationship between angiotensin II (ANG II) and the renal dopaminergic system (RDS) has been reported. Our aim was to study whether renal dopamine and ANG II can interact to modify renal sodium handling and then ...
Atrial natriuretic peptide stimulates dopamine tubular transport by organic cation transporters: A novel mechanism to enhance renal sodium excretion
(Public Library of Science, 2016-07)
The aim of this study was to demonstrate the effects of atrial natriuretic peptide (ANP) on organic cation transporters (OCTs) expression and activity, and its consequences on dopamine urinary levels, Na+ ,K+ -ATPase ...
Utilization of multivariate calibration methods for the study of K+ transport through hydrophobic liquid membranes by using isomeric anions
(Marcel Dekker IncNew YorkEUA, 1999)
Transport of the organic cations gonyautoxin 2/3 epimers, a paralytic shellfish poison toxin, through the human and rat intestinal epitheliums
(2002)
The aim of this work is to study the mechanisms involved in gonyautoxins (GTXs) intestinal absorption. For this purpose, we studied the transport of GTX 2/3 epimers by intestinal epithelial cell lines (IEC-6 and Caco-2) ...
The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats
(Elsevier B.V., 2018-05-01)
Purpose: We investigated the influence of diabetes mellitus (DM), glycemic control with insulin, cimetidine (Oct2 inhibitor) and metformin (Oct2 substrate) on the kinetic disposition of GAB in rats. Main methods: Male ...
Modulação dos transportadores cátions orgânicos e receptor b1 de cininas de camundongos pela metformina
(Universidade Federal de São Paulo (UNIFESP), 2018-09-25)
Objective: The aim of the study was to evaluate the effect of the
modulation of organic cation transporters (OCT and MATE1)
and the
kinin receptor B1 by metformin . Methods: The subjects were divided into
four groups, ...
The complex role of mitochondrial metabolism in plant aluminum resistance
(ELSEVIER SCIENCE LONDON, 2014)