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Rat bone marrow stromal cells and oligonucleotides in pain research
(Humana Press, 2010-02-13)
In the last years, significant progress has been made in the medical treatment of pain. However, pathological pains, such us neuropathic pain, remain refractory to the currently available analgesics. Therefore, new therapeutic ...
Interferon-γ priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG motifs in murine macrophages
(Wiley Blackwell Publishing, Inc, 2009-09)
Recognition of microbial products by macrophages (Mph) stimulates an inflammatory response and plays a critical role in directing the host immune response against infection. In the present work, we showed for the first ...
Transforming growth factor-b1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes
(Elsevier Science (USA), 2002-07-15)
Mouse transformed keratinocytes cultured in the presence of transforming growth factor-b1 (TGF-b1) acquire a set ofmorphological
and functional properties giving rise to a more motile phenotype that expresses mesenchymal ...
IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model
(Springer, 2020-11)
IMT504 is a non-CPG, non-coding synthetic oligodeoxinucleotide (ODN) with immunomodulatory properties and a novel inhibitory role in pain transmission, exerting long-lasting analgesic effects upon multiple systemic ...
Papel da PI3K8 no controle da contratilidade vascular no Diabetes Mellitus I: estudo funcional e eletrofisiológico
(Universidade Federal de Minas GeraisUFMG, 2012-09-13)
Diabetes is associated to damage in several organs and systems including the vascular system. Vascular diseases are the main cause of mortality and morbidity in diabetes patients. However, the mechanisms that determine ...
Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: Involvement of the NO/cGMP/PKG/KATP signaling pathway
(Elsevier Science BvAmsterdamHolanda, 2010)