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In <i>silico</i> Guided Drug Repurposing : Discovery of New Competitive and Non-competitive Inhibitors of Falcipain-2

Alberca, Lucas Nicolás; Chuguransky, Sara Rocío; Álvarez, Cora L.; Talevi, Alan; Salas Sarduy, Emir (2019)

Nuevas terapias en osteoporosis

Autor desconocido (Revista Colombiana de Reumatología, 2016-03)

Osteoporosis is a skeletal system pathology characterised by low bone mineral density and tissue structural deterioration. This condition is associated with high fracture risk that severely compromises quality of life. ...

Odanacatib in the Treatment of Postmenopausal Women With Low Bone Mineral Density: Five Years of Continued Therapy in a Phase 2 Study

Langdahl, Bente; Binkley, Neil; Bone, Henry; Gilchrist, Nigel; Resch, Heinrich; Portales, Jose Rodriguez; Denker, Andrew; Lombardi, Antonio; De Tilleghem, Celine Le Bailly; DaSilva, Carolyn; Rosenberg, Elizabeth; Leung, Albert (WILEY, 2012)

Odanacatib (ODN) is a selective inhibitor of the collagenase cathepsin K that is highly expressed by osteoclasts. In this 2-year, phase 2, dose-ranging trial, postmenopausal women with bone mineral density (BMD) T-scores ...

Continuous treatment with odanacatib for up to 8 years in postmenopausal women with low bone mineral density : a phase 2 study

Rizzoli, R.; Benhamou, C.L.; Halse, J.; Miller, P. D.; Reid, I. R.; Rodríguez, J. A. (2016)

In silico Guided Drug Repurposing: Discovery of New Competitive and Non-competitive Inhibitors of Falcipain-2

Alberca, Lucas Nicolás; Chuguransky, Sara Rocío; Alvarez, Cora Lilia; Talevi, Alan; Salas Sarduy, Emir (Frontiers Media S.A., 2019-08-06)

Malaria is among the leading causes of death worldwide. The emergence of Plasmodium falciparum resistant strains with reduced sensitivity to the first line combination therapy and suboptimal responses to insecticides used ...

Odanacatib for the treatment of postmenopausal osteoporosis : results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

McClung, M.R.; O'Donoghue, M.L.; Papapoulos, S.E.; Bone, H.; Langdahl, B.; Saag, K.G.; Reid, I.R.; Kiel, D.P.; Cavallari, I.; Rodríguez Portales, José; Bonaca, M.P.; Wiviott, S.D.; De Villiers, T.; Ling, X.; Lippuner, K.; Nakamura, T.; Reginster, J.Y.; Roux, C.; Zanchetta, J.; Zerbini, C.A.F.; Park, J.G.; Im, K. (2019)

Discovery of novel falcipain 2 inhibitors by in silico guided drug repositioning

Alberca, Lucas Nicolás; Chuguransky, Sara Rocío; Alvarez, Cora Lilia; Salas Sarduy, Emir; Talevi, Alan (University of Dundee, 2019)

Malaria is a life-threatening condition that continues being one of global leading causes of death worldwide, being themain cause of death globally in the 5-14 year-old population. The disease is caused by parasites from ...