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Characterization of Novel O-Glycans Isolated from Tear and Saliva of Ocular Rosacea Patients
(Amer Chemical Soc, 2013-03-01)
O-Glycans in saliva and tear isolated from patients suffering from ocular rosacea, a form of inflammatory ocular surface disease, were profiled, and their structures were elucidated using high resolution mass spectrometry. ...
Assembly, organization and regulation of cell-surface receptors by lectin–glycan complexes
(Portland Press, 2015-06)
Galectins are a family of β-galactoside-binding lectins carrying at least one consensus sequence in the carbohydrate-recognition domain. Properties of glycosylated ligands, such as N- and O-glycan branching, LacNAc ...
Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
(Cell Press, 2012-03)
Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and ...
Molecular strategies and interactions between representative bacteria of the human gut microbiota during the utilization of glycomacropeptide
(2024)
The human gut microbiota plays an essential role in metabolizing complex dietary compounds that host enzymes cannot degrade. The prebiotic role of milk glycans, such as free human milk oligosaccharides (HMO), currently ...
Biosynthesis of O- N -acetylgalactosamine glycans in the human cell nucleus
(American Society for Biochemistry and Molecular Biology, 2018-12)
Biological functions of nuclear proteins are regulated by post-translational modifications (PTMs) that modulate gene expression and cellular physiology. However, the role of O-linked glycosylation (O-GalNAc) as a PTM of ...
Tunicamycin inhibition of N-glycosylation of alpha-glucosidase from Aspergillus niveus: partial influence on biochemical properties
(SPRINGER, 2010)
Treatment of Aspergillus niveus with 30 mu g tunicamycin/ml did not interfere with alpha-glucosidase production, secretion, or its catalytic properties. Fully- and under-glycosylated forms of the enzyme had similar molecular ...
Aberrant O-glycosylation modulates aggressiveness in neuroblastoma
(Impact Journals, 2018-09)
Neuroblastoma (NB) is the most common pediatric malignancy diagnosed before the first birthday in which MYCN oncogene amplification is associated with poor prognosis. Although aberrant glycosylation is an important actor ...
Cracking the “Sugar Code”: A Snapshot of N- and O-Glycosylation Pathways and Functions in Plants Cells
(Frontiers Media, 2021-02)
Glycosylation is a fundamental co-translational and/or post-translational modification process where an attachment of sugars onto either proteins or lipids can alter their biological function, subcellular location and ...
Extrinsic functions of lectin domains in O-N-acetylgalactosamine glycan biosynthesis
(American Society for Biochemistry and Molecular Biology, 2016-12)
Glycan biosynthesis occurs mainly in Golgi. Molecular organization and functional regulation of this process are not well understood. We evaluated the extrinsic effect of lectin domains (β-trefoil fold) of polypeptide ...
Chitin-like molecules associate with Cryptococcus neoformans glucuronoxylomannan to form a glycan complex with previously unknown properties
(American Society for Microbiology, 2018)