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Development of designed site-directed pseudopeptide-peptido-mimetic immunogens as novel minimal subunit-vaccine candidates for malaria
(Universidad del Rosario, 2010)
Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic ...
Identification of naturally immunogenic B-cell epitopes in Leptospira secreted metalloproteases: novel and promising targets to multi-epitopes vaccines against leptospirosis
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2022)
Trypanosoma cruzi 80 kDa prolyl oligopeptidase (Tc80) as a novel immunogen for Chagas disease vaccine
(Public Library of Science, 2018-03)
Background: Chagas disease, also known as American Trypanosomiasis, is a chronic parasitic disease caused by the flagellated protozoan Trypanosoma cruzi that affects about 8 million people around the world where more than ...
Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside
(Elsevier, 2018-04-25)
Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...
Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection
(Nature Publishing Group, 2017-02)
The parasite Trypanosoma cruzi is the causative agent of Chagas disease, a potentially life-threatening infection that represents a major health problem in Latin America. Several characteristics of this protozoan contribute ...
Identification of naturally immunogenic B-cell epitopes in Leptospira secreted metalloproteases: novel and promising targets to multi-epitopes vaccines against leptospirosis
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2022)
Immunological parameters related to the adjuvant effect of the ordered mesoporous silica SBA-15
(ELSEVIER SCI LTD, 2010)
In 2006, the first report of a nanostructured material as adjuvant was described establishing the effectiveness of the ordered mesoporous SBA-15 silica as an immune adjuvant. The present study evaluated the SBA-15 capacity ...
Oral vaccine based on a surface immunogenic protein mixed with alum promotes a decrease in Streptococcus agalactiae vaginal colonization in a mouse model
(2018)
The Surface Immunogenic Protein (SIP) of Group B Streptococcus (GBS) had been described as a good target for vaccine development. To date, SIP has been reported as a highly conserved protein, and in a mouse model it induces ...
Immunogenicity of Hypothetical Highly Conserved Proteins as Novel Antigens in Anaplasma marginale
(Springer, 2013-10)
Anaplasma marginale is a tick-transmitted Gram-negative intraerythrocytic bacterium and the etiological agent of bovine Anaplasmosis. Even though considerable research efforts have been undertaken, Anaplasmosis vaccine ...