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Identification of Novel Candidate Epitopes on SARS-CoV-2 Proteins for South America: A Review of HLA Frequencies by Country
(Frontiers Media, 2020)
Coronavirus disease (COVID-19), caused by the virus SARS-CoV-2, is already responsible for more than 4.3 million confirmed cases and 295,000 deaths worldwide as of May 15, 2020. Ongoing efforts to control the pandemic ...
Identification of naturally immunogenic B-cell epitopes in Leptospira secreted metalloproteases: novel and promising targets to multi-epitopes vaccines against leptospirosis
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2022)
Automatic Generation of Validated Specific Epitope Sets
(Hindawi, 2015)
Accurate measurement of B and T cell responses is a valuable tool to study autoimmunity, allergies, immunity to pathogens, and host-pathogen interactions and assist in the design and evaluation of T cell vaccines and ...
Development of a novel platform of virus-like particle (VLP) based vaccine against coronavirus 2019 (SARS-CoV-2) by exposing of epitopes: an immunoinformatics approach
The emergence of a rapidly spreading and highly infectious COVID-19 outbreak by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has caused a global pandemic with unprecedented, social and ...
Immunoinformatic analysis of the whole proteome for vaccine design: An application to Clostridium perfringens
(Frontiers Media, 2022)
Clostridium perfringens is a dangerous bacterium and known biological warfare weapon associated with several diseases, whose lethal toxins can produce necrosis in humans. However, there is no safe and fully effective vaccine ...
Identification of naturally immunogenic B-cell epitopes in Leptospira secreted metalloproteases: novel and promising targets to multi-epitopes vaccines against leptospirosis
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2022)
A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity : Application to emerging infectious diseases
(2015-03-03)
Background: Peptide vaccination based on multiple T-cell epitopes can be used to target well-defined ethnic populations. Because the response to T-cell epitopes is restricted by HLA proteins, the HLA specificity of T-cell ...
Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production
(2016-03-03)
Novel vaccination approaches based on rational design of B- and T-cell epitopes - epitope-based vaccines - are making progress in the clinical trial pipeline. The epitope-focused recombinant protein-based malaria vaccine ...
Improved pan-specific MHC class I peptide-binding predictions using a novel representation of the MHC-binding cleft environment
(Wiley, 2014)
Major histocompatibility complex (MHC) molecules play a key role in cell-mediated immune responses presenting bounded peptides for recognition by the immune system cells. Several in silico Methods: have been developed to ...