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Regulation of the Norepinephrine Transporter by Endothelins: A potential therapeutic target
(Elsevier Academic Press Inc, 2015-03)
Neuronal norepinephrine (NE) uptake is a crucial step in noradrenergic neurotransmission that regulates NE concentration in the synaptic cleft. It is a key mechanism mediated by the NE transporter (NET) which takes the ...
Metformin increases norepinephrine transporter expression in placenta of patients with polycystic ovary syndrome
(Verduci Publisher, 2017)
OBJECTIVE: To evaluate the norepinephrine (NE) and placental NE transporter (NET) in women with polycystic ovary syndrome (PCOS) non-treated and treated with metformin during pregnancy.
PATIENTS AND METHODS: We studied ...
Angiotensin-(1-7) through Mas receptor up-regulates neuronal norepinephrine transporter via Akt and Erk1/2-dependent pathways
(Wiley Blackwell Publishing, Inc, 2012-01)
As angiotensin (Ang) (1-7) decreases norepinephrine (NE) content in the synaptic cleft, we investigated the effect of Ang-(1-7) on NE neuronal uptake in spontaneously hypertensive rats. [ 3H]-NE neuronal uptake was measured ...
Gestational stress, placental norepinephrine transporter and offspring fertility
(BioScientifica Ltd., 2017)
© 2017 Society for Reproduction and Fertility.Chronic cold stress produces adrenergic overload that can affect fetal development. The placental norepinephrine transporter (NET) clears norepinephrine (NE) from both maternal ...
Amphetamine derivatives as Monoamine Oxidase Inhibitors
(Frontiers Media, 2020)
Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or antidepressant effects. The mechanisms of action underlying these ...
Bupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male rats
(Wiley-Blackwell, 2015)
Bupropion is a dopamine (DA) and norepinephrine (NE) reuptake inhibitor used as smoking cessation and antidepressant drug with a lower incidence of male sexual dysfunction. We showed previously that sibutramine, a ...
Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra
(BLACKWELL PUBLISHING LTD, 2005-03)
The role of dopamine in iron uptake into catecholaminergic neurons, and dopamine oxidation to aminochrome and its one-electron reduction in iron-mediated neurotoxicity, was studied in RCSN-3 cells, which express both ...