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Estrutura e variabilidade da região 3’não-traduzida dos genes HLA-A, HLA-C e HLA-G e perfil de ligação de microRNAs
(Universidade Estadual Paulista (Unesp), 2018-02-26)
O complexo gênico de Antígenos Leucocitário Humanos (HLA) é a região mais variável do genoma humano. Os genes HLA de classe I são divididos em clássicos e não clássicos, a depender de suas funções primárias, níveis de ...
Insights into HLA-G genetics provided by worldwide haplotype diversity
(Frontiers Research Foundation, 2014-10-06)
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function ...
Classical and non-classical HLA molecules and p16(INK4a) expression in precursors lesions and invasive cervical cancer
(ELSEVIER SCIENCE BV, 2008)
Objectives: Viruses and turnout cells may regulate the expression of HLA molecules on the cell surface to escape immune system surveillance. Absence of classical HLA class I molecules may impair the action of specific ...
Diversidade genética e variantes estruturais do bloco alfa do complexo principal de histocompatibilidade humano
(Universidade Estadual Paulista (Unesp), 2020-02-18)
O MHC humano possui cerca de 224 genes, a maioria deles está relacionada de alguma forma com o sistema imunitário. O bloco alfa do MHC humano compreende genes importantes do complexo HLA, como HLA-F, HLA-G e HLA-A. HLA-F ...
The role of HLA-G molecule and HLA-G gene polymorphisms in tumors, viral hepatitis, and parasitic diseases
(Frontiers Research Foundation, 2015-02-02)
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic properties, HLA-G expression is expected to be deleterious when present in tumor cells and in cells chronically infected by viruses, whereas ...
Insights into HLA-G genetics provided by worldwide haplotype diversity
(Frontiers Research Foundation, 2015)
HLA-F coding and regulatory segments variability determined by massively parallel sequencing procedures in a Brazilian population sample
(2016-10-01)
Human Leucocyte Antigen F (HLA-F) is a non-classical HLA class I gene distinguished from its classical counterparts by low allelic polymorphism and distinctive expression patterns. Its exact function remains unknown. It ...
HLA-E coding and 3' untranslated region variability determined by next-generation sequencing in two West-African population samples
(Elsevier B. V., 2015)
HLA-E is a non-classical Human Leucocyte Antigen class I gene with immunomodulatory properties. Whereas HLA-E expression usually occurs at low levels, it is widely distributed amongst human tissues, has the ability to bind ...
HLA-E regulatory and coding region variability and haplotypes in a Brazilian population sample
(2017-11-01)
The HLA-E gene is characterized by low but wide expression on different tissues. HLA-E is considered a conserved gene, being one of the least polymorphic class I HLA genes. The HLA-E molecule interacts with Natural Killer ...