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Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism
(Elsevier, 2020)
Nitrofurans (5-nitro-2-hydrazonylfuran as pharmacophore) are a group of widely used antimicrobial drugs but also associated to a variety of side effects. The molecular mechanisms that underlie the cytotoxic effects of ...
2-Nitrofurans as dienophiles in Diels–Alder reactions
(Pergamon-Elsevier Science Ltd, 2005-12)
2-Nitrofuran derivatives are studied in Diels-Alder reactions under thermal conditions. In contrast to 2-acilfurans, they proved to be efficient dienophiles.
Voltammetric study of nitro radical anion generated from some nitrofuran compounds of pharmacological significance
(WILEY-V C H VERLAG GMBH, 2003-01)
The electrochemical behavior of 2-(5-amino- 1,3,4-oxadiazolyl)-5-nitrofuran (NF359) and its comparison with well known drugs such as nifurtimox (NFX) and nitrofurazone (NFZ) in protic, mixed and aprotic media by cyclic ...
Potent 5-nitrofuran derivatives inhibitors of Trypanosoma cruzi growth: Electrochemical, spectroscopic and biological studies
(2011)
Cyclic voltammetry and electron spin resonance techniques were used in the investigation of several potential antiprotozoal containing thiosemicarbazone and carbamate nitrofurans. In the electrochemical behaviour, a ...
ESR spin trapping studies of free radicals generated from nitrofuran derivative analogues of nifurtimox by electrochemical and Trypanosoma cruzi reduction
(TAYLOR & FRANCIS LTD, 2003-08)
Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
Square wave voltammetry of nitrofurans in aqueous media using a carbon fiber microelectrode
(Springer, 2018)
The nitrofuran compounds exhibit a wide spectrum of biological action, and the understanding of their reduction mechanism can contribute to a better comprehension of their biological action. In this sense, the electrochemical ...
5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene
(Pergamon-Elsevier Science Ltd, 2009-11)
Chagas disease represents a serious public health problem in South America. The first line of treatment is Nifurtimox and Benznidazole which generate toxic effects in treated patients. We have recently shown that a number ...
Synthesis and Evaluation of the Antifungal and Toxicological Activity of Nitrofuran Derivatives
(2022-03-01)
Fungal diseases affect more than 1 billion people worldwide. The constant global changes, the advent of new pandemics, and chronic diseases favor the diffusion of fungal pathogens such as Candida, Cryptococcus, Aspergillus, ...
Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives
(PERGAMON PRESS, 2003)