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Cyclic voltammetry and digital-simulation of the electroreduction of ortho- and meta-nitro aryl 1,4-dihydropyridines
(SOCIEDAD CHILENA DE QUÍMICA, 1999)
Cyclic voltammetry and digital-simulation of the electroreduction of ortho- and meta-nitro aryl 1,4-dihydropyridines
(SOCIEDAD CHILENA DE QUÍMICA, 1999)
Nitro aryl 1,4-dihydropyridine derivatives: Effects of Trypanosoma cruzi
(1997)
A series of nitro aryl 1,4-dihydropyridine derivatives produced inhibition of both cell growth and oxygen consumption on Tulahuen and LQ strains, and clone Dm 28c of epimastigotes of Trypanosoma cruzi. Nicardipine was found ...
1,4-Dihydropyridines: Reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation
(TAYLOR & FRANCIS, 2004-07)
In the present paper, a direct quenching of radical species by a number of synthesized nitrosoaryl 1,4-dihydropyridines and their parent nitroaryl 1,4-dihydropyridines was determined in aqueous media at pH 7.4. These two ...
Cyclic voltammetry and digital simulation of the electroreduction of ortho- and meta-nitro aryl 1,4-dihydropyridines
(1999)
Cyclic voltammetry (CV) and digital simulation methods are utilized to elucidate the mechanism of electrochemical reduction of a series of nitro aryl 1,4-dihydropyridines in protic (aqueous) and mixed media. The experimental ...
Antioxidant effects of 1,4-dihydropyridine and nitroso aryl derivatives on the Fe+3/ascorbate-stimulated lipid peroxidation in rat brain slices
(PERGAMON-ELSEVIER SCIENCE, 1998-09)
1. Lipid peroxidation in rat brain slices was induced by Fe+3/ascorbate.
2. Brain lipid peroxidation, as measured by malondialdehyde formation, was inhibited by all the tested nitro aryl 1,4-dihydropyridine derivatives ...
Antioxidant effects of 1,4-dihydropyridine and niitroso aryl derivatives on the Fe+3/ascorbate-stimulated lipid peroxidation in rat brain slices
(1998)
Lipid peroxidation in rat brain slices was induced by Fe+3/ascorbate.Brain lipid peroxidation, as measured by malondialdehyde formation, was inhibited by all the tested nitro aryl 1,4-dihydropyridine derivatives over a ...
Electrochemical generation and reactivity of free radical redox intermediates from ortho-and meta-nitro substituted 1,4-dihydropyridines
(1997)
This paper reports a comprehensive study by cyclic voltammetry on the electrochemical characteristics and the reactivity of the one-electron reduction product from a series of nitro aryl 1,4-dihydropyridines in mixed and ...
Nitroaryl-1,4-dihydropyridines as antioxidants against rat liver microsomes oxidation induced by iron/ascorbate, Nitrofurantoin and naphthalene
(PERGAMON-ELSEVIER SCIENCE LTD, 2007)
1,4-Dihydropyridines (DHPs) used in the treatment of cardiovascular diseases, are calcium channel antagonists and also antioxidant agents. These drugs are metabolized through cytochrome P-450 oxidative system, majority ...
Liver microsomal biotransformation of nitro-aryl drugs: Mechanism for potential oxidative stress induction
(JOHN WILEY & SONS LTD, 2004-11)
Toxic effects of several nitro-aryl drugs are attributed to the nitro-reduction that may be suffered in vivo, a reaction that may be catalysed by different reductases. One of these enzymes is NADPH-cytochrome P450 reductase, ...