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Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations
(Springer, 2014-08)
Rationale:Nicotine is a major active ingredient in tobacco and plays a major role in tobacco addiction. In rodents, repeated nicotine administration produces behavioral responses related to its addictive properties, such ...
Myrciaine, a new nicotinic ester from Myrcia blanchetiana (Myrtaceae)
(2013)
A nicotinic ester with a new carbon skeleton named myrciaine was obtained from hexane extract of stems of Myrcia blanchetiana using chromatographic methods and from leaves by supercritical CO2. The molecular structure was ...
Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
(Elsevier Science, 2014-09)
The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine ...
Atividade da acetilcolinsterase e da porfobilinogênio-sintase e alteração comportamental de ratos expostos à nicotina
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2007-03-16)
Tobacco smoking and nicotine replacement therapy are the main form of nicotine exposure. The drug abuse for humans often begins during adolescence and the exposure to nicotine during this phase produces long-term alterations, ...
Sensibilidade da enzima acetilcolinesterase (e.c. 3.1.1.7) à nicotina in vitro e in vivo
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2005-08-18)
This work valued the sensibility of the acetylcholinesterase from different sources and brain regions at nicotine in vitro, and the effects of the acute and subchronic exposures at the alkaloid on the brain acetylcholinesterase ...
Nicotinic acid increases cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia El ácido nicotínico aumenta el transporte celular de colesterol de las lipoproteínas de alta densidad en pacientes con hipoalfali
(Sociedad Medica de Santiago, 2015)
© 2015, Sociedad Medica de Santiago. All Rights Reserved.Background: Plasma high density lipoproteins (HDL) are involved in reverse cholesterol transport mediated by the scavenger receptor class B type I (SR-BI). Nicotinic ...
A new synthetic methodology for pyridinic sucrose esters and their antibacterial effects against Gram-positive and Gram-negative strains
(2020-03-01)
Described are the development of a new synthetic method using ultrasonic irradiation and sodium methoxide as catalyst for a series of pyridinic sucrose esters (py-SEs), derived from transesterification of sucrose with ...