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A new method for next-generation sequencing of the full hepatitis b virus genome from a clinical specimen: Impact for virus genotyping
(2020-09-01)
Hepatitis B virus (HBV) is an enveloped virus that induces chronic liver disease. HBV has been classified into eight genotypes (A–H) according to its genome sequence by using Sanger sequencing or reverse hybridization. ...
Hla-mapper: An application to optimize the mapping of HLA sequences produced by massively parallel sequencing procedures
(2018-09-01)
A challenging task when more than one HLA gene is evaluated together by second-generation sequencing is to achieve a reliable read mapping. The polymorphic and repetitive nature of HLA genes might bias the read mapping ...
HLA-G variability and haplotypes detected by massively parallel sequencing procedures in the geographicaly distinct population samples of Brazil and Cyprus
(2017-03-01)
The HLA-G molecule presents immunomodulatory properties that might inhibit immune responses when interacting with specific Natural Killer and T cell receptors, such as KIR2DL4, ILT2 and ILT4. Thus, HLA-G might influence ...
Next-Generation Sequencing Reveals Pathway Activations and New Routes to Targeted Therapies in Cutaneous Metastatic Melanoma
(Lippincott Williams & Wilkins, 2017-01-01)
Background: Comprehensive genomic profiling of clinical samples by next-generation sequencing (NGS) can identify one or more therapy targets for the treatment of metastatic melanoma (MM) with a single diagnostic test. ...
Targeted next generation sequencing for CFTR gene analysis in a Brazilian cohort of cystic fibrosis patients
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
Utilização de ferramentas bioinformáticas para busca, análise e compreensão de informações oriundas de Next Generation Sequencing e descoberta de miRNAs conservados utilizando mirDeep2Use of bioinformatics tools to search, analyze and understand information from Next Generation Sequencing and discovery of conserved miRNAs using mirDeep2
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Biotecnologia, 2022)
HLA-F coding and regulatory segments variability determined by massively parallel sequencing procedures in a Brazilian population sample
(2016-10-01)
Human Leucocyte Antigen F (HLA-F) is a non-classical HLA class I gene distinguished from its classical counterparts by low allelic polymorphism and distinctive expression patterns. Its exact function remains unknown. It ...