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Evaluation of trypanocidal and antioxidant activities of a selected series of 3-amidocoumarins
(Bentham Science, 2018)
Background: Neglected diseases are becoming more prevalent due to globalization. This has inspired active research in the development of new drugs for the treatment of parasitic diseases such as Chagas disease. Objectives: ...
Natural and synthetic naphthoquinones active against Trypanosoma cruzi: An initial step towards new drugs for chagas disease
(2011)
Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side ...
Evaluation of proline analogs as trypanocidal agents through the inhibition of a Trypanosoma cruzi proline transporter
(Elsevier Science, 2017-08)
Background: Trypanosoma cruzi, the etiological agent of Chagas disease, uses proline as its main carbon source, essential for parasite growth and stage differentiation in epimastigotes and amastigotes. Since proline is ...
Evaluation of Trypanocidal and Antioxidant Activities of a Selected Series of 3-amidocoumarins
(2018)
Background: Neglected diseases are becoming more prevalent due to globalization. This has inspired active research in the development of new drugs for the treatment of parasitic diseases such as Chagas disease. Objectives: ...
A trypanocidal phenazine derived from beta-lapachone
(American Chemical Society, 2020)
New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities
(Elsevier, 2011)
Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-N-oxide quinoxaline-2- carbonitrile derivatives were synthesized and evaluated for their in vitro ...