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Canine neutrophils activate effector mechanisms in response to Leishmania infantum
(2017-12-15)
Canine leishmaniosis caused by L. infantum is a severe zoonotic disease. Although macrophages are the definitive host cells, neutrophils are the first cells to encounter the parasite soon after its inoculation in the dermis ...
Platelets: New bricks in the building of neutrophil extracellular traps
(Frontiers Research Foundation, 2016-07)
In addition to being key elements in hemostasis and thrombosis, platelets have an important role in the inflammatory and innate immune response. This activity is associated with their capability to recognize pathogens ...
Intracellular and extracellular effector activity of mouse neutrophils in response to cutaneous and visceral Leishmania parasites
(Elsevier B.V., 2019-01-01)
Neutrophils are short-lived phagocytic cells equipped with several receptors for pathogen recognition and phagocytosis and have intracellular and extracellular effector mechanisms that can inactivate pathogens. Leishmaniases ...
The role of neutrophils in severe sepsis
(LIPPINCOTT WILLIAMS & WILKINS, 2008)
Neutrophils are key effectors of the innate immune response. Reduction of neutrophil migration to infection sites is associated with a poor outcome in sepsis. We have demonstrated a failure of neutrophil migration in lethal ...
Modulation of γδ T-cell activation by neutrophil elastase
(Wiley Blackwell Publishing, Inc, 2017-09)
γδ T cells are non-conventional, innate-like T cells, characterized by a restricted T-cell receptor repertoire. They participate in protective immunity responses against extracellular and intracellular pathogens, tumour ...
Role of inflammatory mediators in priming, activation, and deformability of bovine neutrophils
(Amer Veterinary Medical Assoc, 2000-05-01)
Objective-To determine the capacity of inflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), platelet-activating factor (PAF), lipopolysaccharide (LPS), and leukotoxin to prime, activate, ...
Role of inflammatory mediators in priming, activation, and deformability of bovine neutrophils
(Amer Veterinary Medical Assoc, 2000-05-01)
Objective-To determine the capacity of inflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), platelet-activating factor (PAF), lipopolysaccharide (LPS), and leukotoxin to prime, activate, ...
Quercetin reduces Staphylococcus aureus interaction with neutrophils
(2011-09-01)
Flavonoids, including quercetin, have been reported to modulate the ability of Staphylococcus aureus to adhere to host tissue without exhibiting direct antibacterial activity. In the present study, we evaluated the interaction ...
The role of neutrophils in neuro-immune modulation
(Elsevier B.V., 2020-01-01)
Neutrophils are peripheral immune cells that represent the first recruited innate immune defense against infections and tissue injury. However, these cells can also induce overzealous responses and cause tissue damage. ...
Melatonin and its kynurenin-like oxidation products affect the microbicidal activity of neutrophils
(Elsevier B.V., 2006-02-01)
Activated phagocytes oxidize the hormone melatonin to N-1-acethyl-N-2-formyl-5-methoxykynuramine (AFMK) in a superoxide anion- and myeloperoxidase-dependent reaction. We examined the effect of melatonin, AFMK and its ...