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Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
(Research Trends, 2013-09)
Neurotensin is a basic tridecapeptide which can act as a neuromodulator or a neurotransmitter and binds to a group of receptors. Neurotensin is able to inhibit Na+, K+-ATPase activity, an effect blocked by the presence of ...
Neurotensin inhibits neuronal Na+, K+-ATPase activity through high affinity peptide receptor
(Elsevier Science Inc, 2000)
Postnatal nitric oxide inhibition modifies neurotensin effect on ATPase activity
(Springer/Plenum Publishers, 2011-12)
We have previously showed that peptide neurotensin inhibits neuronal Na+, K+-ATPase activity, an effect which involves high affinity neurotensin receptor. Nitric oxide (NO) acts as a neurotransmitter or as a neuromodulator ...
High affinity receptors but not low affinity receptors for neurotensin are involved in neuronal Na/K-ATPase inhibition by the peptide
(Research Trends, 2013-07)
Neurotensin acts as a neuromodulator or as a neurotransmitter that binds to a group of receptors. Two of the receptors, namely NTS1 and NTS2, bind to neurotensin with high affinity and low affinity, respectively. Neurotensin ...
Neurotensin inhibitory effect on [ 3h]-ouabain binding to striatal membranes is inverted by administration of clozapine
(Nova Science Publishers, 2021)
Previous work indicates that peptide neurotensin inhibits synaptosomal membrane Na+, K+-ATPase activity. Anatomical and biochemical evidences indicate a relationship between neurotensinergic and dopaminergic systems and ...
Changes in [3H]-ouabain and [3H]-neurotensin binding to rat cerebral cortex membranes after administration of antipsychotic drugs haloperidol and clozapine
(Elsevier Science Inc, 2017-03)
Evidences indicate the relationship between neurotensinergic and dopaminergic systems. Neurotensin inhibits synaptosomal membrane Na+, K+-ATPase activity, an effect blocked by SR 48692, antagonist for high affinity neurotensin ...
The low affinity neurotensin receptor antagonist levocabastine impairs brain nitric oxide synthesis and mitochondrial function by independent mechanisms
(Wiley Blackwell Publishing, Inc, 2017-12)
Neurotensin is known to inhibit neuronal Na+, K+‐ATPase, an effect that is rescued by nitric oxide (NO) synthase inhibition. However, whether the neurotensinergic and the nitrergic systems are independent pathways, or are ...
Neurotensin decreases high affinity [ 3H]-ouabain binding to cerebral cortex membranes
(Elsevier Science, 2011-12)
Previous work from this laboratory showed the ability of neurotensin to inhibit synaptosomal membrane Na +, K +-ATPase activity, the effect being blocked by SR 48692, a non-peptidic antagonist for high affinity neurotensin ...
Antipsychotic-like effects of a neurotensin receptor type 1 agonist
(Elsevier, 2016-05)
Although neurotensin (NT) analogs are known to produce antipsychotic-like effects, the therapeutic possibility of a brain penetrant NTS1 agonist in treating psychiatric disorders has not been well studied. Here, we examined ...
The neurotensin receptor antagonist, SR48692, attenuates the expression of amphetamine-induced behavioural sensitisation in mice
(Elsevier B.V., 2001-09-28)
The effects of acute administration of the neurotensin receptor antagonist. SR48692 (2-{[1-(7-chloroquinolin-4- yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-carbonyl]amino}adamantane-2-carboxylic acid), on amphetamine-induced ...