Bipolar disorder is associated with increases in mortality rates due to metabolic complications when compared to the general population. the selfish brain theory postulates that the CNS modulates energy metabolism in the ...

The rise in life expectancy has in turn led to an increase in the proportion of older adults with bipolar disorder (OABD), with the consequent need to improve understanding of the clinical features of this population. ...

This letter is written in response to a review recently published in the journal. The aim is to highlight a potential meth- odological limitation common to many studies comparing bipolar patients with few previous episodes ...

Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g., C-reactive protein, and pro-inflammatory cytokines, e.g., interleukin-6. Supporting ...

Bipolar Disorder (BD) has been conceptualized as both a cyclic and a progressive disorder. Mechanisms involved in neuroprogression in BD remain largely unknown although several non-mutually exclusive models have been ...

Objective The hypothesis of a progressive nature of neuropsychological deficits in bipolar disorders is often accepted as an axiom by many clinicians and researchers in the field. However, contradictory pieces of data and ...

Background The aim of this study was to estimate the relationship between clinical course and trajectory of neurocognitive functioning during a follow-up period in a sample of euthymic bipolar patients. Methods Fifty-one ...