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Peripheral mechanisms underlying the essential role of P2X7 receptors in the development of inflammatory hyperalgesia
(Elsevier Science BvAmsterdamHolanda, 2010)
Reduced nerve injury-induced neuropathic pain in kinin B-1 receptor knock-out mice
(Soc Neuroscience, 2005-03-02)
Injury to peripheral nerves often results in a persistent neuropathic pain condition that is characterized by spontaneous pain, allodynia, and hyperalgesia. Nerve injury is accompanied by a local inflammatory reaction in ...
Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice
(Quintessence Publishing Co. Inc., 2011)
AIMS:
To develop a behavioral model in mice that is capable of mimicking some distinctive symptoms of human posttraumatic trigeminal neuropathic pain such as spontaneous pain, cold allodynia, and chemical÷inflammatory ...
Antinociceptive Synergism of Gabapentin and Nortriptyline in Mice with Partial Sciatic Nerve Ligation
(Karger, 2015)
Background and Methods: Neuropathic pain results from nerve injury, and gabapentin, an antiepileptic drug, has been approved for the treatment of several types of neuropathic pain. On the other hand, nortriptyline, an ...
Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain
(Elsevier Science BvAmsterdamHolanda, 2003)
Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation
(Pergamon-elsevier Science LtdOxfordInglaterra, 2013)
The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
Crotoxin (CTX). a neurotoxin isolated from the venom of the South American rattlesnake Crotalus durissus terrificus. induces analgesia. In this study, we evaluated the antinociceptive effect of CTX in a model of neuropathic ...
Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors
(ELSEVIER SCIENCE BV, 2008)
Neuropathic pain is an important clinical problem and it is usually resistant to the current therapy. We have recently characterized a novel analgesic peptide, crotalphine, from the venom of the South American rattlesnake ...
P2X3 and P2X2/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE(2) or dopamine
(Elsevier Science BvAmsterdamHolanda, 2010)
Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia
(Elsevier Science BvAmsterdamHolanda, 2009)