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Mostrando ítems 1-10 de 1522
Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug - Evidence for chronic encephalopathic processes following ischemia
(Amer Heart Assoc, 1996-09-01)
Background and Purpose It has been recognized that post ischemic pharmacological interventions may delay the evolution of neuronal damage rather than provide long-lasting neuroprotection. Also, fever complicates recovery ...
The reactions of specific neuron types to intestinal ischemia in the guinea pig enteric nervous system
(SPRINGER, 2009)
Damage following ischemia and reperfusion (I/R) is common in the intestine and can be caused during abdominal surgery, in several disease states and following intestinal transplantation. Most studies have concentrated on ...
Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-κappa B activation and cause neuronal damage in vivo in a murine model
(2023)
Background: Helicobacter pylori (Hp) infects the stomach of 50% of the world's population. Importantly, chronic infection by this bacterium correlates with the appearance of several extra-gastric pathologies, including ...
Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection
(Springer, 2017-01)
cAMP response element-binding (CREB) protein is a cellular transcription factor that mediates responses to different physiological and pathological signals. Using a model of human neuronal cells we demonstrate herein, that ...
Predictors of damage accrual in systemic lupus erythematosus: a longitudinal observational study with focus on neuropsychological factors and anti-neuronal antibodies
(Facultad de Medicina y Ciencia, 2019)
Objective Central nervous system disease occurs in over 20% of patients with systemic lupus erythematosus (SLE) resulting in major morbidity and damage. Cognitive dysfunction is common in SLE, but the cause remains uncertain ...
An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells
(2002)
Intracellular reactive iron is a source of free radicals and a possible cause of cell damage. In this study, we analyzed the changes in iron homeostasis generated by iron accumulation in neuroblastoma (N2A) cells and ...
Iron and glutathione at the crossroad of redox metabolism in neurons
(2006)
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In
particular, there is increasing evidence that iron progressively accumulates in the brain with age and that ...
Damaging effects of BMAA on retina neurons and Müller glial cells
(Elsevier Science Ltd, 2020-11-01)
B–N-methylamino-L-alanine (BMAA), a cyanotoxin produced by most cyanobacteria, has been proposed to cause long term damages leading to neurodegenerative diseases, including Amyotrophic Lateral Sclerosis/Parkinsonism Dementia ...
TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death
(Taylor & Francis, 2017)
Cerebral ischemia-reperfusion injury triggers a deleterious process ending in neuronal death. This process has two components, a glutamate-dependent and a glutamate-independent mechanism. In the glutamate-independent ...
Quantification of Fas protein in CSF of patients with neurocysticercosis
(Academia Brasileira de Neurologia - ABNEURO, 2012-04-01)
Neurocysticercosis is a parasitic disease that affects the central nervous system. The objective of this study was to investigate the correlation between neuronal death evaluated by the quantification of Fas apoptotic ...