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Outside-binding site mutations modify the active site's shapes in neuraminidase from influenza A H1N1
(Wiley, 2013)
The recent occurrence of 2009 influenza A (H1N1) pandemic as well as others has raised concern of a far more dangerous outcome should this virus becomes resistant to current drug therapies. The number of clinical cases ...
Análise molecular da mutação HIS275TIR isolada na Neuraminidase do H1N1 resistente ao oseltamivir
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS, 2017-04-19)
The latest influenza pandemic occurred in the year 2009, caused by the strain of influenza A (H1N1), and popularly known as influenza A or swine flu, generated concern to the global health agencies. With a symptomatic ...
Expression of recombinant Influenza A H1N1 neuraminidase in Rachiplusia nu larvae
(Research Trends, 2014-10)
Two recombinant baculoviruses carrying the fulllength or transmembrane-deleted neuraminidase (NA) genes of influenza were constructed with the aim to select the best strategy to express this viral antigenic protein in ...
Molecular modeling studies demonstrate key mutations that could affect the ligand recognition by influenza AH1N1 neuraminidase
(Springer, 2015)
The goal of this study was to identify neuraminidase (NA) residue mutants from human influenza AH1N1 using sequences from 1918 to 2012. Multiple alignment studies of complete NA sequences (5732) were performed. Subsequently, ...
Theoretical analysis of the neuraminidase epitope of the Mexican A H1N1 influenza strain, and experimental studies on its interaction with rabbit and human hosts
(Springer, 2013)
The neuraminidase (NA) epitope from the Mexican AH1N1 influenza virus was identified by using sequences registered at the GenBank during the peak of a pandemic (from April 2009 to October 2010). First, NA protein sequences ...