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Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs
(John Wiley & Sons Inc, 2009-12)
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic ...
Wnt-7a Induces Presynaptic Colocalization of 7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons
(Society for Neuroscience, 2007-05-16)
Nicotinic acetylcholine receptors (nAChRs) contribute significantly to hippocampal function. Alpha7-nAChRs are present in presynaptic sites in hippocampal neurons and may influence transmitter release, but the factors that ...
Avaliação da expressão gênica e proteica dos receptores nicotínicos em modelo in vitro de infecção por SARS-CoV-2 com e sem superexpressão de ECA2
(Universidade Federal de São Paulo, 2023-02-27)
Introdução: O SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) é o vírus causador da COVID-19 (Coronavírus disease 2019), doença decretada pandêmica em 2020. A entrada do vírus na célula hospedeira ocorre após ...
An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse
(Nature Publishing Group, 2009-07)
Nicotinic acetylcholine receptors (nAChRs) mediate fast excitatory neurotransmission in neurons and muscles. To identify nAChR accessory proteins, which may regulate their expression or function, we performed tandem affinity ...
Morphological aspects of neuromuscular junctions and gene expression of nicotinic acetylcholine receptors (nAChRs) in skeletal muscle of rats with heart failure
(Springer, 2011-12-01)
HF is syndrome initiated by a reduction in cardiac function and it is characterized by the activation of compensatory mechanisms. Muscular fatigue and dyspnoea are the more common symptoms in HF; these may be due in part ...
Nicotinic receptor M3 transmembrane domain: Position 8′ contributes to channel gating
(American Society for Pharmacology and Experimental Therapeutics, 2002-08-01)
The nicotinic acetylcholine receptor (nAChR) is a pentamer of homologous subunits with composition α2βεδ in adult muscle. Each subunit contains four transmembrane domains (M1-M4). Position 8′ of the M3 domain is phenylalanine ...
Búsqueda de sitios de unión a ligandos en receptores nicotínicos de acetilcolina humano de tipo α7 y α4(2)β2(3)
(Universidad de Talca (Chile). Escuela de Bioinformática., 2014)
Relationship between α7 nAChR and apoptosis in human lymphocytes
(Elsevier Science, 2005-03)
The presence of nicotinic receptors (nAChRs) in blood cells has been demonstrated. However, little is known about their functional roles. We have detected mRNA of a7 nAChR in peripheral human lymphocytes and determined ...